2cm7: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2cm7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CM7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2cm7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CM7 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IZD:ISOTHIAZOLIDINONE+ANALOG'>IZD</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IZD:ISOTHIAZOLIDINONE+ANALOG'>IZD</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a5y|1a5y]], [[1aax|1aax]], [[1bzc|1bzc]], [[1bzh|1bzh]], [[1bzj|1bzj]], [[1c83|1c83]], [[1c84|1c84]], [[1c85|1c85]], [[1c86|1c86]], [[1c87|1c87]], [[1c88|1c88]], [[1ecv|1ecv]], [[1een|1een]], [[1eeo|1eeo]], [[1g1f|1g1f]], [[1g1g|1g1g]], [[1g1h|1g1h]], [[1g7f|1g7f]], [[1g7g|1g7g]], [[1gfy|1gfy]], [[1i57|1i57]], [[1jf7|1jf7]], [[1kak|1kak]], [[1kav|1kav]], [[1l8g|1l8g]], [[1lqf|1lqf]], [[1nl9|1nl9]], [[1nny|1nny]], [[1no6|1no6]], [[1nwe|1nwe]], [[1nwl|1nwl]], [[1nz7|1nz7]], [[1oem|1oem]], [[1oeo|1oeo]], [[1oes|1oes]], [[1oet|1oet]], [[1oeu|1oeu]], [[1oev|1oev]], [[1ony|1ony]], [[1onz|1onz]], [[1pa1|1pa1]], [[1ph0|1ph0]], [[1ptt|1ptt]], [[1ptu|1ptu]], [[1ptv|1ptv]], [[1pty|1pty]], [[1pxh|1pxh]], [[1pyn|1pyn]], [[1q1m|1q1m]], [[1q6j|1q6j]], [[1q6m|1q6m]], [[1q6n|1q6n]], [[1q6p|1q6p]], [[1q6s|1q6s]], [[1q6t|1q6t]], [[1qxk|1qxk]], [[1sug|1sug]], [[1t48|1t48]], [[1t49|1t49]], [[1t4j|1t4j]], [[1wax|1wax]], [[1xbo|1xbo]], [[2azr|2azr]], [[2b07|2b07]], [[2b4s|2b4s]], [[2bgd|2bgd]], [[2bge|2bge]], [[2cm2|2cm2]], [[2cm3|2cm3]], [[2cm8|2cm8]], [[2cma|2cma]], [[2cmb|2cmb]], [[2cmc|2cmc]], [[2cne|2cne]], [[2cnf|2cnf]], [[2cng|2cng]], [[2cnh|2cnh]], [[2cni|2cni]], [[2f6f|2f6f]], [[2f6t|2f6t]], [[2f6v|2f6v]], [[2f6w|2f6w]], [[2f6y|2f6y]], [[2f6z|2f6z]], [[2f70|2f70]], [[2f71|2f71]], [[2fjm|2fjm]], [[2fjn|2fjn]], [[2hnp|2hnp]], [[2hnq|2hnq]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a5y|1a5y]], [[1aax|1aax]], [[1bzc|1bzc]], [[1bzh|1bzh]], [[1bzj|1bzj]], [[1c83|1c83]], [[1c84|1c84]], [[1c85|1c85]], [[1c86|1c86]], [[1c87|1c87]], [[1c88|1c88]], [[1ecv|1ecv]], [[1een|1een]], [[1eeo|1eeo]], [[1g1f|1g1f]], [[1g1g|1g1g]], [[1g1h|1g1h]], [[1g7f|1g7f]], [[1g7g|1g7g]], [[1gfy|1gfy]], [[1i57|1i57]], [[1jf7|1jf7]], [[1kak|1kak]], [[1kav|1kav]], [[1l8g|1l8g]], [[1lqf|1lqf]], [[1nl9|1nl9]], [[1nny|1nny]], [[1no6|1no6]], [[1nwe|1nwe]], [[1nwl|1nwl]], [[1nz7|1nz7]], [[1oem|1oem]], [[1oeo|1oeo]], [[1oes|1oes]], [[1oet|1oet]], [[1oeu|1oeu]], [[1oev|1oev]], [[1ony|1ony]], [[1onz|1onz]], [[1pa1|1pa1]], [[1ph0|1ph0]], [[1ptt|1ptt]], [[1ptu|1ptu]], [[1ptv|1ptv]], [[1pty|1pty]], [[1pxh|1pxh]], [[1pyn|1pyn]], [[1q1m|1q1m]], [[1q6j|1q6j]], [[1q6m|1q6m]], [[1q6n|1q6n]], [[1q6p|1q6p]], [[1q6s|1q6s]], [[1q6t|1q6t]], [[1qxk|1qxk]], [[1sug|1sug]], [[1t48|1t48]], [[1t49|1t49]], [[1t4j|1t4j]], [[1wax|1wax]], [[1xbo|1xbo]], [[2azr|2azr]], [[2b07|2b07]], [[2b4s|2b4s]], [[2bgd|2bgd]], [[2bge|2bge]], [[2cm2|2cm2]], [[2cm3|2cm3]], [[2cm8|2cm8]], [[2cma|2cma]], [[2cmb|2cmb]], [[2cmc|2cmc]], [[2cne|2cne]], [[2cnf|2cnf]], [[2cng|2cng]], [[2cnh|2cnh]], [[2cni|2cni]], [[2f6f|2f6f]], [[2f6t|2f6t]], [[2f6v|2f6v]], [[2f6w|2f6w]], [[2f6y|2f6y]], [[2f6z|2f6z]], [[2f70|2f70]], [[2f71|2f71]], [[2fjm|2fjm]], [[2fjn|2fjn]], [[2hnp|2hnp]], [[2hnq|2hnq]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cm7 RCSB], [http://www.ebi.ac.uk/pdbsum/2cm7 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cm7 RCSB], [http://www.ebi.ac.uk/pdbsum/2cm7 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein-tyrosine-phosphatase]] | [[Category: Protein-tyrosine-phosphatase]] | ||
[[Category: Ala, P J | [[Category: Ala, P J]] | ||
[[Category: Becker-Pasha, M | [[Category: Becker-Pasha, M]] | ||
[[Category: Bower, M | [[Category: Bower, M]] | ||
[[Category: Burn, T C | [[Category: Burn, T C]] | ||
[[Category: Combs, A P | [[Category: Combs, A P]] | ||
[[Category: Douty, B | [[Category: Douty, B]] | ||
[[Category: Gonneville, L | [[Category: Gonneville, L]] | ||
[[Category: Hillman, M C | [[Category: Hillman, M C]] | ||
[[Category: Hollis, G F | [[Category: Hollis, G F]] | ||
[[Category: Klabe, R | [[Category: Klabe, R]] | ||
[[Category: Polam, P | [[Category: Polam, P]] | ||
[[Category: Reid, B G | [[Category: Reid, B G]] | ||
[[Category: Wasserman, Z | [[Category: Wasserman, Z]] | ||
[[Category: Wayland, B | [[Category: Wayland, B]] | ||
[[Category: Wei, M | [[Category: Wei, M]] | ||
[[Category: Wynn, R | [[Category: Wynn, R]] | ||
[[Category: Yue, E W | [[Category: Yue, E W]] | ||
[[Category: Endoplasmic reticulum]] | [[Category: Endoplasmic reticulum]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||