1ity: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ity]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ITY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ITY FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ity]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ITY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ITY FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ba5|1ba5]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ba5|1ba5]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ity FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ity OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ity RCSB], [http://www.ebi.ac.uk/pdbsum/1ity PDBsum], [http://www.topsan.org/Proteins/RSGI/1ity TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ity FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ity OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ity RCSB], [http://www.ebi.ac.uk/pdbsum/1ity PDBsum], [http://www.topsan.org/Proteins/RSGI/1ity TOPSAN]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/TERF1_HUMAN TERF1_HUMAN]] Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.<ref>PMID:16166375</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Konig, P | [[Category: Konig, P]] | ||
[[Category: Nagadoi, A | [[Category: Nagadoi, A]] | ||
[[Category: Nishikawa, T | [[Category: Nishikawa, T]] | ||
[[Category: Nishimura, Y | [[Category: Nishimura, Y]] | ||
[[Category: Okamura, H | [[Category: Okamura, H]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Rhodes, D | [[Category: Rhodes, D]] | ||
[[Category: Dna binding]] | [[Category: Dna binding]] | ||
[[Category: Dna binding protein]] | [[Category: Dna binding protein]] | ||
[[Category: Helix-turn-helix]] | [[Category: Helix-turn-helix]] | ||
[[Category: Myb domain]] | [[Category: Myb domain]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Telomere]] | [[Category: Telomere]] | ||