1ed1: Difference between revisions
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|PDB= 1ed1 |SIZE=350|CAPTION= <scene name='initialview01'>1ed1</scene>, resolution 2.1Å | |PDB= 1ed1 |SIZE=350|CAPTION= <scene name='initialview01'>1ed1</scene>, resolution 2.1Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=IPA:ISOPROPYL ALCOHOL'>IPA</scene> | |LIGAND= <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= GAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Simian immunodeficiency virus - mac]) | |GENE= GAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Simian immunodeficiency virus - mac]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1ecw|1ECW]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ed1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ed1 OCA], [http://www.ebi.ac.uk/pdbsum/1ed1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ed1 RCSB]</span> | |||
}} | }} | ||
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[[Category: Roy, P.]] | [[Category: Roy, P.]] | ||
[[Category: Stuart, D I.]] | [[Category: Stuart, D I.]] | ||
[[Category: trimeric association]] | [[Category: trimeric association]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:00:11 2008'' | ||
Revision as of 20:00, 30 March 2008
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| , resolution 2.1Å | |||||||
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| Ligands: | |||||||
| Gene: | GAG (Simian immunodeficiency virus - mac) | ||||||
| Related: | 1ECW
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF SIMIAN IMMUNODEFICIENCY VIRUS MATRIX ANTIGEN (SIV MA) AT 100K.
OverviewOverview
Simian immunodeficiency virus (SIV) is closely related to human immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some 50% sequence identity. MA is a component of Pr55Gag, the sole protein required for assembly of the virion shell. MA targets Pr55 to the plasma membrane, and facilitates incorporation of the virus envelope protein and assembly of the Pr55Gag shell. Cleavage of Pr55 by the viral protease produces the mature protein of relative molecular mass 17-18K, which underlies the host-derived membrane and is important in both virus entry and nuclear localization of the virion core. Here we report the crystal structure of SIV MA. The molecule forms a trimer consistent with oligomerization in vitro, the observed virion architecture, and various biological properties of MA.
About this StructureAbout this Structure
1ED1 is a Single protein structure of sequence from Simian immunodeficiency virus - mac. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of SIV matrix antigen and implications for virus assembly., Rao Z, Belyaev AS, Fry E, Roy P, Jones IM, Stuart DI, Nature. 1995 Dec 14;378(6558):743-7. PMID:7501025
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