4muf: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4muf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MUF FirstGlance]. <br>
<table><tr><td colspan='2'>[[4muf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MUF FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2DJ:(2-{[(4-TERT-BUTYLPHENYL)SULFONYL]CARBAMOYL}-5-METHOXY-1H-INDOL-1-YL)ACETIC+ACID'>2DJ</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene><br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2DJ:(2-{[(4-TERT-BUTYLPHENYL)SULFONYL]CARBAMOYL}-5-METHOXY-1H-INDOL-1-YL)ACETIC+ACID'>2DJ</scene>, <scene name='pdbligand=EOH:ETHANOL'>EOH</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mq6|4mq6]], [[4mue|4mue]], [[4mug|4mug]], [[4muh|4muh]], [[4mui|4mui]], [[4muj|4muj]], [[4muk|4muk]], [[4mul|4mul]], [[4mun|4mun]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4mq6|4mq6]], [[4mue|4mue]], [[4mug|4mug]], [[4muh|4muh]], [[4mui|4mui]], [[4muj|4muj]], [[4muk|4muk]], [[4mul|4mul]], [[4mun|4mun]]</td></tr>
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantoate--beta-alanine_ligase Pantoate--beta-alanine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.1 6.3.2.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantoate--beta-alanine_ligase Pantoate--beta-alanine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.1 6.3.2.1] </span></td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4muf RCSB], [http://www.ebi.ac.uk/pdbsum/4muf PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4muf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4muf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4muf RCSB], [http://www.ebi.ac.uk/pdbsum/4muf PDBsum]</span></td></tr>
<table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref> 
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pantoate--beta-alanine ligase]]
[[Category: Pantoate--beta-alanine ligase]]
[[Category: Blundell, T L.]]
[[Category: Blundell, T L]]
[[Category: Silvestre, H L.]]
[[Category: Silvestre, H L]]
[[Category: Atp binding]]
[[Category: Atp binding]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Ligase-ligase inhibitor complex]]
[[Category: Pantoate-ligase]]
[[Category: Pantoate-ligase]]

Revision as of 19:14, 25 December 2014

Crystal structure of pantothenate synthetase in complex with 2-(2-(4-tert-butylphenylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acidCrystal structure of pantothenate synthetase in complex with 2-(2-(4-tert-butylphenylsulfonylcarbamoyl)-5-methoxy-1H-indol-1-yl)acetic acid

Structural highlights

4muf is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Pantoate--beta-alanine ligase, with EC number 6.3.2.1
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.[1]

References

  1. ↑ Zheng R, Blanchard JS. Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase. Biochemistry. 2001 Oct 30;40(43):12904-12. PMID:11669627

4muf, resolution 2.50Å

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