Villin: Difference between revisions

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{{STRUCTURE_2k6n| right| PDB=2k6n  |  SCENE=Villin/Cv/1 |CAPTION=Human supervillin headpiece, [[2k6n]] }}
{{STRUCTURE_2k6n| right| PDB=2k6n  |  SCENE=Villin/Cv/1 |CAPTION=Human supervillin headpiece, [[2k6n]] }}


[[Villin]] (VIL) is an actin-binding protein.  It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>.  '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin.  '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.  '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton. images on the left and right  correspond to one representative villin structure, ''i.e.'' the human supervillin headpiece ([[2k6n]]).
* [[Villin]] (VIL) is an actin-binding protein.  It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin<ref>PMID:10480879</ref>.<br />
 
*   '''Supervillin (SVIL)''' contains numerous gelsolin-like domains in its C-terminal and interacts with actin.<br />
<br />
* '''Advillin (AVIL)''' is another actin-binding protein in the [[gelsolin]] superfamily which is expressed in the peripheral sensory neurons.<br />
* '''Cytovillin (CVIL) or ezrin or villin-2''' serves as intermediate between plasma membrane and actin cytoskeleton.  


== 3D Structures of Villin ==
== 3D Structures of Villin ==

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Alexander Berchansky, Michal Harel, David Canner, Jaime Prilusky, Joel L. Sussman