Thymidylate kinase: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
Michal Harel (talk | contribs)
31,761 edits
No edit summary
Michal Harel (talk | contribs)
31,761 edits
No edit summary
Line 6: Line 6:


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


===TMK===
*Thymidylate kinase


[[2cck]], [[4f4i]] – SaTMK  – ''Staphylococcus aureus'' <br />
**[[2cck]], [[4f4i]] – SaTMK  – ''Staphylococcus aureus'' <br />
[[2pbr]] – TMK  – ''Aquifex aeolicus'' <br />
**[[2pbr]] – TMK  – ''Aquifex aeolicus'' <br />
[[2plr]] – TMK  – ''Sulfolobus tokodaii'' <br />
**[[2plr]] – TMK  – ''Sulfolobus tokodaii'' <br />
[[3ld9]] – TMK – ''Ehrlichia chafeensis''<br />
**[[3ld9]] – TMK – ''Ehrlichia chafeensis''<br />
[[3v9p]] – TMK – ''Burkholderia thailandensis''<br />
**[[3v9p]] – TMK – ''Burkholderia thailandensis''<br />
[[3uwk]], [[3uwo]] – PaTMK – ''Pseudomonas aeruginosa''<br />
**[[3uwk]], [[3uwo]] – PaTMK – ''Pseudomonas aeruginosa''<br />


===TMK complex with HIV prodrug AZT derivative===
*Thymidylate kinase complex with HIV prodrug AZT derivative


[[2tmk]] – yTMK + AZTP <br />
**[[2tmk]] – yTMK + AZTP <br />
[[4eaq]] – SaTMK + AZTP <br />
**[[4eaq]] – SaTMK + AZTP <br />
[[4gmd]] – PaTMK + AZTP <br />
**[[4gmd]] – PaTMK + AZTP <br />
[[4tmk]], [[5tmp]] – TMK + AZTP – ''Escherichia coli''<br />
**[[4tmk]], [[5tmp]] – TMK + AZTP – ''Escherichia coli''<br />
[[1w2h]] – MtTMK + AZTP - ''Mycobacterium tuberculosis'' <br />
**[[1w2h]] – MtTMK + AZTP - ''Mycobacterium tuberculosis'' <br />
[[1e98]], [[1e99]], [[1e9d]] – hTMK (mutant) + AZTP + ADP<br />
**[[1e98]], [[1e99]], [[1e9d]] – hTMK (mutant) + AZTP + ADP<br />


===TMK complex with nucleotides===
*Thymidylate kinase complex with nucleotides


[[2v54]] – VvTMK  + TDP – Vaccinia virus<br />
**[[2v54]] – VvTMK  + TDP – Vaccinia virus<br />
[[2w0s]] – VvTMK + brivudin-MP <br />
**[[2w0s]] – VvTMK + brivudin-MP <br />
[[1tmk]] – yTMK + dTMP - yeast<br />
**[[1tmk]] – yTMK + dTMP - yeast<br />
[[4e5u]] – PaTMK + dTMP <br />
**[[4e5u]] – PaTMK + dTMP <br />
[[2ccg]], [[2ccj]], [[4dwj]] – SaTMK + dTMP <br />
**[[2ccg]], [[2ccj]], [[4dwj]] – SaTMK + dTMP <br />
[[1g3u]], [[1gsi]], [[1n5i]], [[1n5k]] – MtTMK + dTMP <br />
**[[1g3u]], [[1gsi]], [[1n5i]], [[1n5k]] – MtTMK + dTMP <br />
[[1w2g]] – MtTMK + thymidine  <br />
**[[1w2g]] – MtTMK + thymidine  <br />
[[1gtv]] – MtTMK + TDP  <br />
**[[1gtv]] – MtTMK + TDP  <br />
[[1n5j]] – MtTMK + TDP  + TTP<br />
**[[1n5j]] – MtTMK + TDP  + TTP<br />
[[1n5l]] – MtTMK + TDP + dTMP <br />
**[[1n5l]] – MtTMK + TDP + dTMP <br />
[[1mrs]] – MtTMK + UMP derivative  <br />
**[[1mrs]] – MtTMK + UMP derivative  <br />
[[3uxm]], [[4esh]] – PaTMK + deoxy thymidine derivative <br />
**[[3uxm]], [[4esh]] – PaTMK + deoxy thymidine derivative <br />
[[3hjn]] – TMK + ADP + TDP – ''Thermotoga maritima''<br />
**[[3hjn]] – TMK + ADP + TDP – ''Thermotoga maritima''<br />
[[1e2d]], [[1e2e]], [[1e2f]], [[1e9e]], [[1e9f]] – hTMK (mutant) + ADP + dTMP - human<br />
**[[1e2d]], [[1e2e]], [[1e2f]], [[1e9e]], [[1e9f]] – hTMK (mutant) + ADP + dTMP - human<br />
[[1e9f]] – hTMK (mutant) + ADP + dTMP - human<br />
**[[1e9f]] – hTMK (mutant) + ADP + dTMP - human<br />
[[4edh]] – PaTMK + ADP + dTMP <br />
**[[4edh]] – PaTMK + ADP + dTMP <br />
[[3lv8]] – VcTMK + ADP + dTMP  + TDP – ''Vibrio cholerae''<br />
**[[3lv8]] – VcTMK + ADP + dTMP  + TDP – ''Vibrio cholerae''<br />
[[3n2i]] – VcTMK + thymidine  + thymidine deoxy-thymidine<br />
**[[3n2i]] – VcTMK + thymidine  + thymidine deoxy-thymidine<br />
[[1e9b]] – hTMK (mutant) + azido-TMP + APPNP<br />
**[[1e9b]] – hTMK (mutant) + azido-TMP + APPNP<br />
[[1e9c]] – hTMK (mutant) + dTMP + APPNP<br />
**[[1e9c]] – hTMK (mutant) + dTMP + APPNP<br />
[[1nmx]] – hTMK (mutant) + F-TMP + ADP<br />
**[[1nmx]] – hTMK (mutant) + F-TMP + ADP<br />
[[1nmy]], [[1nn0]], [[1nnz]], [[1nn1]], [[1nn3]], [[1nn5]], [[1nmz]] – hTMK (mutant) + dTMP derivative + APPNP<br />
**[[1nmy]], [[1nn0]], [[1nnz]], [[1nn1]], [[1nn3]], [[1nn5]], [[1nmz]] – hTMK (mutant) + dTMP derivative + APPNP<br />
[[2xx3]] – hTMK + dTMP derivative + ADP<br />
**[[2xx3]] – hTMK + dTMP derivative + ADP<br />
[[2yof]], [[2yog]], [[2yoh]] - TMK + thymidine analog – ''Plasmodium falciparum''<br />
**[[2yof]], [[2yog]], [[2yoh]] - TMK + thymidine analog – ''Plasmodium falciparum''<br />


===Other TMK binary complexes===
*Other thymidylate kinase binary complexes


[[4gfd]], [[4hlc]], [[4hld]], [[4hej]], [[4hdc]] – SaTMK + antibacterial drug <br />
**[[4gfd]], [[4hlc]], [[4hld]], [[4hej]], [[4hdc]] – SaTMK + antibacterial drug <br />
[[4gsy]] – SaTMK + inhibitor<br />
**[[4gsy]] – SaTMK + inhibitor<br />
[[4mqb]] – SaTMK + MES<br />
**[[4mqb]] – SaTMK + MES<br />


===TMK complex with bisubstrate inhibitor===
*Thymidylate kinase complex with bisubstrate inhibitor


[[1mrn]] – MtTMK + TP5A  <br />
**[[1mrn]] – MtTMK + TP5A  <br />
[[3tmk]] – yTMK + TP5A <br />
**[[3tmk]] – yTMK + TP5A <br />
[[1e9a]] – hTMK (mutant) + azido-TP5A + ADP<br />
**[[1e9a]] – hTMK (mutant) + azido-TP5A + ADP<br />
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 16:01, 14 December 2014

Template:STRUCTURE 1e99

Thymidylate kinase (TMK) catalyzes the conversion of thymidine-5’-phosphate (dTMP) and ATP to thymidine-5’-diphosphate and ADP. TMK is important for DNA synthesis. Inhibitors of TMK include bisubstrate compounds of the type TP(n)X where P(n) are the number of phosphoryl groups and X is the nucleoside moiety of the acceptor. The TMK inhibitor azido-dTMP (AZTP) is an HIV AZT prodrug metabolite.

3D Structures of thymidylate kinase3D Structures of thymidylate kinase

Updated on 14-December-2014

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=Thymidylate_kinase&oldid=2102942"