4c16: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4c16]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C16 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C16 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4c16]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C16 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C16 FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WC:(S)-CYCLOHEXYL+LACTIC+ACID'>4WC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Q6Z:(1R,2R,3S)-3-METHYLCYCLOHEXANE-1,2-DIOL'>Q6Z</scene><br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WC:(S)-CYCLOHEXYL+LACTIC+ACID'>4WC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Q6Z:(1R,2R,3S)-3-METHYLCYCLOHEXANE-1,2-DIOL'>Q6Z</scene></td></tr>
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c17|4c17]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4c17|4c17]]</td></tr>
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c16 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c16 RCSB], [http://www.ebi.ac.uk/pdbsum/4c16 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c16 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c16 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c16 RCSB], [http://www.ebi.ac.uk/pdbsum/4c16 PDBsum]</span></td></tr>
<table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/LYAM2_HUMAN LYAM2_HUMAN]] Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.<ref>PMID:1689848</ref> 
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Binder, F P.C.]]
[[Category: Binder, F P.C]]
[[Category: Ernst, B.]]
[[Category: Ernst, B]]
[[Category: Jakob, R P.]]
[[Category: Jakob, R P]]
[[Category: Maier, T.]]
[[Category: Maier, T]]
[[Category: Preston, R C.]]
[[Category: Preston, R C]]
[[Category: Sager, C P.]]
[[Category: Sager, C P]]
[[Category: Antagonist]]
[[Category: Antagonist]]
[[Category: C-type lectin]]
[[Category: C-type lectin]]

Revision as of 01:50, 25 December 2014

E-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic antagonistE-selectin lectin, EGF-like and two SCR domains complexed with glycomimetic antagonist

Structural highlights

4c16 is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , , ,
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[LYAM2_HUMAN] Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.[1]

References

  1. ↑ Hession C, Osborn L, Goff D, Chi-Rosso G, Vassallo C, Pasek M, Pittack C, Tizard R, Goelz S, McCarthy K, et al.. Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions. Proc Natl Acad Sci U S A. 1990 Mar;87(5):1673-7. PMID:1689848

4c16, resolution 1.93Å

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