2wf7: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wf7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_lactis"_lister_1873 "bacterium lactis" lister 1873]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2wf7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_lactis"_lister_1873 "bacterium lactis" lister 1873]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WF7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WF7 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=G7P:6,7-DIDEOXY-7-PHOSPHONO-BETA-D-GLUCO-HEPTOPYRANOSE'>G7P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALF:TETRAFLUOROALUMINATE+ION'>ALF</scene>, <scene name='pdbligand=G7P:6,7-DIDEOXY-7-PHOSPHONO-BETA-D-GLUCO-HEPTOPYRANOSE'>G7P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z4n|1z4n]], [[1z4o|1z4o]], [[2wf6|2wf6]], [[1o03|1o03]], [[2wf5|2wf5]], [[1zol|1zol]], [[2wfa|2wfa]], [[1o08|1o08]], [[1lvh|1lvh]], [[2wf8|2wf8]], [[2wf9|2wf9]], [[4c4r|4c4r]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z4n|1z4n]], [[1z4o|1z4o]], [[2wf6|2wf6]], [[1o03|1o03]], [[2wf5|2wf5]], [[1zol|1zol]], [[2wfa|2wfa]], [[1o08|1o08]], [[1lvh|1lvh]], [[2wf8|2wf8]], [[2wf9|2wf9]], [[4c4r|4c4r]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-phosphoglucomutase Beta-phosphoglucomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.6 5.4.2.6] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf7 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wf7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wf7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wf7 RCSB], [http://www.ebi.ac.uk/pdbsum/2wf7 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PGMB_LACLA PGMB_LACLA]] Catalyzes the interconversion of D-glucose 1-phosphate (G1P) and D-glucose 6-phosphate (G6P), forming beta-D-glucose 1,6-(bis)phosphate (beta-G16P) as an intermediate. The beta-phosphoglucomutase (Beta-PGM) acts on the beta-C(1) anomer of G1P. Glucose or lactose are used in preference to maltose, which is only utilized after glucose or lactose has been exhausted. It plays a key role in the regulation of the flow of carbohydrate intermediates in glycolysis and the formation of the sugar nucleotide UDP-glucose.<ref>PMID:9084169</ref> <ref>PMID:15005616</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Bacterium lactis lister 1873]] | [[Category: Bacterium lactis lister 1873]] | ||
[[Category: Beta-phosphoglucomutase]] | [[Category: Beta-phosphoglucomutase]] | ||
[[Category: Alizadeh, T | [[Category: Alizadeh, T]] | ||
[[Category: Baxter, N J | [[Category: Baxter, N J]] | ||
[[Category: Bermel, W | [[Category: Bermel, W]] | ||
[[Category: Blackburn, G M | [[Category: Blackburn, G M]] | ||
[[Category: Bowler, M W | [[Category: Bowler, M W]] | ||
[[Category: Cliff, M J | [[Category: Cliff, M J]] | ||
[[Category: Hollfelder, F | [[Category: Hollfelder, F]] | ||
[[Category: Hounslow, A M | [[Category: Hounslow, A M]] | ||
[[Category: Pollard, S | [[Category: Pollard, S]] | ||
[[Category: Waltho, J P | [[Category: Waltho, J P]] | ||
[[Category: Webster, C E | [[Category: Webster, C E]] | ||
[[Category: Williams, N H | [[Category: Williams, N H]] | ||
[[Category: Haloacid dehalogenase superfamily]] | [[Category: Haloacid dehalogenase superfamily]] | ||
[[Category: Isomerase]] | [[Category: Isomerase]] | ||
[[Category: Phosphotransferase]] | [[Category: Phosphotransferase]] | ||
[[Category: Transition state analogue]] | [[Category: Transition state analogue]] | ||