Growth factor receptor-bound protein: Difference between revisions
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<StructureSection load='1tze' size='350' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry [[1tze]])' scene=''> | <StructureSection load='1tze' size='350' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry [[1tze]])' scene=''> | ||
'''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction. '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway. '''GRB10''' interacts with insulin receptor and insulin-like growth factor receptors | '''Growth factor receptor-bound proteins''' (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains. <br /> | ||
* '''GRB2''' links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction.<br /> | |||
* '''GRB7''' interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway.<br /> | |||
* '''GRB10''' interacts with insulin receptor and insulin-like growth factor receptors. For additional details on GRB10 see [[Grb10 SH2 Domain]].<br /> | |||
==3D structures of Grb== | ==3D structures of Grb== | ||
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[[2auh]] – hGRB14 BPS domain + insulin receptor kinase domain<br /> | [[2auh]] – hGRB14 BPS domain + insulin receptor kinase domain<br /> | ||
[[4k81]] – hGRB14 RA and PH domains + GTPase Hras<br /> | [[4k81]] – hGRB14 RA and PH domains + GTPase Hras<br /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||