4tqb: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4tqb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TQB FirstGlance]. <br> | <table><tr><td colspan='2'>[[4tqb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TQB FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34K:(2E)-2-{2-[4-(4-BROMOPHENYL)-1,3-THIAZOL-2-YL]HYDRAZINYLIDENE}-3-(2-NITROPHENYL)PROPANOIC+ACID'>34K</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34K:(2E)-2-{2-[4-(4-BROMOPHENYL)-1,3-THIAZOL-2-YL]HYDRAZINYLIDENE}-3-(2-NITROPHENYL)PROPANOIC+ACID'>34K</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5-TRIPHOSPHATE'>MGT</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tpw|4tpw]], [[4tqc|4tqc]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tpw|4tpw]], [[4tqc|4tqc]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tqb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tqb RCSB], [http://www.ebi.ac.uk/pdbsum/4tqb PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tqb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tqb RCSB], [http://www.ebi.ac.uk/pdbsum/4tqb PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Jenni, S | [[Category: Jenni, S]] | ||
[[Category: Papadopoulos, E | [[Category: Papadopoulos, E]] | ||
[[Category: Wagner, G | [[Category: Wagner, G]] | ||
[[Category: Allosteric]] | [[Category: Allosteric]] | ||
[[Category: Eif4e]] | [[Category: Eif4e]] | ||
[[Category: Protein binding]] | [[Category: Protein binding]] | ||
[[Category: Translation initiation inhibitor]] | [[Category: Translation initiation inhibitor]] | ||