1b9w: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1b9w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_cynomolgi Plasmodium cynomolgi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B9W FirstGlance]. <br> | <table><tr><td colspan='2'>[[1b9w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_cynomolgi Plasmodium cynomolgi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B9W FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b9w RCSB], [http://www.ebi.ac.uk/pdbsum/1b9w PDBsum]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b9w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1b9w RCSB], [http://www.ebi.ac.uk/pdbsum/1b9w PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Plasmodium cynomolgi]] | [[Category: Plasmodium cynomolgi]] | ||
[[Category: Bentley, G A | [[Category: Bentley, G A]] | ||
[[Category: Chitarra, V | [[Category: Chitarra, V]] | ||
[[Category: Holm, I | [[Category: Holm, I]] | ||
[[Category: Longacre, S | [[Category: Longacre, S]] | ||
[[Category: Candidate malaria vaccine]] | [[Category: Candidate malaria vaccine]] | ||
[[Category: Msp-1]] | [[Category: Msp-1]] | ||
[[Category: Surface antigen]] | [[Category: Surface antigen]] | ||
[[Category: Surface protein]] | [[Category: Surface protein]] | ||
Revision as of 11:27, 22 December 2014
C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGIC-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedThe C-terminal proteolytic processing product of merozoite surface protein 1 (MSP1) appears essential for successful erythrocyte invasion by the malarial parasite, Plasmodium. We have determined the crystal structure at 1.8 A resolution of a soluble baculovirus-recombinant form of the protein from P. cynomolgi, which confers excellent protective efficacy in primate vaccination trials. The structure comprises two EGF-like domains, and sequence comparisons strongly suggest that the same conformation is present in all species of Plasmodium, including P. falciparum and P. vivax, which are pathogenic in man. In particular, conserved interdomain contacts between the two EGF modules should preserve the compact form of the molecule in all species. Implications of the crystal structure for anti-malarial vaccine development are discussed. The crystal structure of C-terminal merozoite surface protein 1 at 1.8 A resolution, a highly protective malaria vaccine candidate.,Chitarra V, Holm I, Bentley GA, Petres S, Longacre S Mol Cell. 1999 Apr;3(4):457-64. PMID:10230398[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References |
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