4ky4: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ky4]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KY4 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ky4]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KY4 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=04J:AMINOPTERIN'>04J</scene>, <scene name='pdbligand=1UE:2-AMINO-5-(PHENYLSULFANYL)-3,9-DIHYDRO-4H-PYRIMIDO[4,5-B]INDOL-4-ONE'>1UE</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=04J:AMINOPTERIN'>04J</scene>, <scene name='pdbligand=1UE:2-AMINO-5-(PHENYLSULFANYL)-3,9-DIHYDRO-4H-PYRIMIDO[4,5-B]INDOL-4-ONE'>1UE</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eil|4eil]], [[4kya|4kya]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4eil|4eil]], [[4kya|4kya]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ky4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ky4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ky4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ky4 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ky4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ky4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ky4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ky4 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/DRTS_TOXGO DRTS_TOXGO]] Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP (By similarity). | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Anderson, K S | [[Category: Anderson, K S]] | ||
[[Category: Sharma, H | [[Category: Sharma, H]] | ||
[[Category: Bifunctional]] | [[Category: Bifunctional]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Synthase]] | [[Category: Synthase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||