Dual specificity phosphatase: Difference between revisions
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{{STRUCTURE_1ohe| PDB=1ohe | SIZE=400 | SCENE= |right|CAPTION=Human Cdc14B2 core domain complex with peptide (PDB code [[1ohe]]). }} | |||
__NOTOC__ | |||
'''Dual specificity phosphatase''' (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:<br /> | |||
• Slingshot phosphatase<br /> | |||
• Phosphatase of regenerating liver<br /> | |||
• Cdc14<br /> | |||
• Cdc25<br /> | |||
• PTEN<br /> | |||
• Myotubularin<br /> | |||
• MAPK phosphatase see [[MAP kinase phosphatase]]<br /> | |||
==3D structures of dual specificity phosphatase== | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
===slingshot phosphatase (SSH)=== | |||
[[2nt2]] – hSSH-2L catalytic domain - human<br /> | |||
===Phosphatase of regenerating liver (RPL)=== | |||
[[1xm2]] – hPRL-1 (mutant)<br /> | |||
[[1zck]], [[1x24]] – rPRL-1 - rat<br /> | |||
[[1zcl]] – rPRL-1 (mutant)<br /> | |||
[[1r6h]], [[1v3a]], [[2mbc]] – hPRL-3 - NMR<br /> | |||
===Cdc14=== | |||
[[1ohc]], [[1ohd]] – hCdc14B2 core domain <br /> | |||
[[1ohe]] – hCdc14B2 core domain + peptide<br /> | |||
===Cdc25=== | |||
[[1qb0]], [[1cwr]], [[1cws]], [[1cwt]], [[1ym9]], [[1ymd]], [[1ymk]], [[1yml]], [[1ys0]], [[2uzq]] – hCdc25B catalytic domain <br /> | |||
[[2a2k]], [[2ifd]], [[2ifv]] – hCdc25B catalytic domain (mutant)<br /> | |||
===Phosphoinositide phosphatase PTEN=== | |||
[[1d5r]] – hPTEN (mutant)<br /> | |||
===Myotubularin-related protein (MTMR)=== | |||
[[1zvr]] – hMTMR2 PH-gram and phosphatase domains (mutant)<br /> | |||
[[1zsq]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate<br /> | |||
[[1m7r]], [[1lw3]] - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate<br /> | |||
[[2yf0]] – hMTMR6<br /> | |||
===MAPK phosphatase=== | |||
[[MAP kinase phosphatase]] | |||
[[Category:Topic Page]] | |||
Revision as of 11:54, 19 June 2014
Dual specificity phosphatase (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:
• Slingshot phosphatase
• Phosphatase of regenerating liver
• Cdc14
• Cdc25
• PTEN
• Myotubularin
• MAPK phosphatase see MAP kinase phosphatase
3D structures of dual specificity phosphatase3D structures of dual specificity phosphatase
Updated on 19-June-2014
slingshot phosphatase (SSH)slingshot phosphatase (SSH)
2nt2 – hSSH-2L catalytic domain - human
Phosphatase of regenerating liver (RPL)Phosphatase of regenerating liver (RPL)
1xm2 – hPRL-1 (mutant)
1zck, 1x24 – rPRL-1 - rat
1zcl – rPRL-1 (mutant)
1r6h, 1v3a, 2mbc – hPRL-3 - NMR
Cdc14Cdc14
1ohc, 1ohd – hCdc14B2 core domain
1ohe – hCdc14B2 core domain + peptide
Cdc25Cdc25
1qb0, 1cwr, 1cws, 1cwt, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq – hCdc25B catalytic domain
2a2k, 2ifd, 2ifv – hCdc25B catalytic domain (mutant)
Phosphoinositide phosphatase PTENPhosphoinositide phosphatase PTEN
1d5r – hPTEN (mutant)
1zvr – hMTMR2 PH-gram and phosphatase domains (mutant)
1zsq - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate
1m7r, 1lw3 - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate
2yf0 – hMTMR6