4cyv: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cyv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/mallard/sweden/51/2002_(h10n2)) Influenza a virus (a/mallard/sweden/51/2002 (h10n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CYV FirstGlance]. <br> | <table><tr><td colspan='2'>[[4cyv]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/mallard/sweden/51/2002_(h10n2)) Influenza a virus (a/mallard/sweden/51/2002 (h10n2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CYV FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cyw|4cyw]], [[4cyz|4cyz]], [[4cz0|4cz0]], [[4d00|4d00]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cyw|4cyw]], [[4cyz|4cyz]], [[4cz0|4cz0]], [[4d00|4d00]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cyv RCSB], [http://www.ebi.ac.uk/pdbsum/4cyv PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cyv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cyv RCSB], [http://www.ebi.ac.uk/pdbsum/4cyv PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/E0YNJ7_9INFA E0YNJ7_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Collins, P J | [[Category: Collins, P J]] | ||
[[Category: Gamblin, S J | [[Category: Gamblin, S J]] | ||
[[Category: Haire, L F | [[Category: Haire, L F]] | ||
[[Category: Martin, S R | [[Category: Martin, S R]] | ||
[[Category: McCauley, J W | [[Category: McCauley, J W]] | ||
[[Category: Skehel, J J | [[Category: Skehel, J J]] | ||
[[Category: Vachieri, S G | [[Category: Vachieri, S G]] | ||
[[Category: Walker, P A | [[Category: Walker, P A]] | ||
[[Category: Xiong, X | [[Category: Xiong, X]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||