3op5: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3op5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OP5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3op5]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OP5 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=REB:[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETONITRILE'>REB</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=REB:[4-({4-[(5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETONITRILE'>REB</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VRK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VRK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3op5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3op5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3op5 RCSB], [http://www.ebi.ac.uk/pdbsum/3op5 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3op5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3op5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3op5 RCSB], [http://www.ebi.ac.uk/pdbsum/3op5 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry. | [[http://www.uniprot.org/uniprot/VRK1_HUMAN VRK1_HUMAN]] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry. | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Allerston, C K | [[Category: Allerston, C K]] | ||
[[Category: Arrowsmith, C H | [[Category: Arrowsmith, C H]] | ||
[[Category: Berridge, G | [[Category: Berridge, G]] | ||
[[Category: Bountra, C | [[Category: Bountra, C]] | ||
[[Category: Brenner, B | [[Category: Brenner, B]] | ||
[[Category: Chalk, R | [[Category: Chalk, R]] | ||
[[Category: Das, S | [[Category: Das, S]] | ||
[[Category: Delft, F von | [[Category: Delft, F von]] | ||
[[Category: Edwards, A M | [[Category: Edwards, A M]] | ||
[[Category: Elkins, J M | [[Category: Elkins, J M]] | ||
[[Category: Eswaran, J | [[Category: Eswaran, J]] | ||
[[Category: Fedorov, O | [[Category: Fedorov, O]] | ||
[[Category: Filippakopoulos, P | [[Category: Filippakopoulos, P]] | ||
[[Category: Gileadi, O | [[Category: Gileadi, O]] | ||
[[Category: Keates, T | [[Category: Keates, T]] | ||
[[Category: King, O | [[Category: King, O]] | ||
[[Category: Knapp, S | [[Category: Knapp, S]] | ||
[[Category: Krojer, T | [[Category: Krojer, T]] | ||
[[Category: Rellos, P | [[Category: Rellos, P]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Savitsky, P | [[Category: Savitsky, P]] | ||
[[Category: Uttarkar, S | [[Category: Uttarkar, S]] | ||
[[Category: Weigelt, J | [[Category: Weigelt, J]] | ||
[[Category: Adenosine triphosphate]] | [[Category: Adenosine triphosphate]] | ||
[[Category: Amino acid sequence]] | [[Category: Amino acid sequence]] | ||
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[[Category: Protein folding]] | [[Category: Protein folding]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
[[Category: Surface entropy reduction]] | [[Category: Surface entropy reduction]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||