1bg1: Difference between revisions
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|PDB= 1bg1 |SIZE=350|CAPTION= <scene name='initialview01'>1bg1</scene>, resolution 2.25Å | |PDB= 1bg1 |SIZE=350|CAPTION= <scene name='initialview01'>1bg1</scene>, resolution 2.25Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2'-DEOXYCYTIDINE-5'-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bg1 OCA], [http://www.ebi.ac.uk/pdbsum/1bg1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bg1 RCSB]</span> | |||
}} | }} | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:00:09 2008'' | ||
Revision as of 19:00, 30 March 2008
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| , resolution 2.25Å | |||||||
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| Ligands: | , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
TRANSCRIPTION FACTOR STAT3B/DNA COMPLEX
OverviewOverview
STAT proteins are a family of eukaryotic transcription factors that mediate the response to a large number of cytokines and growth factors. Upon activation by cell-surface receptors or their associated kinases, STAT proteins dimerize, translocate to the nucleus and bind to specific promoter sequences on their target genes. Here we report the first crystal structure of a STAT protein bound to its DNA recognition site at 2.25 A resolution. The structure provides insight into the various steps by which STAT proteins deliver a response signal directly from the cell membrane to their target genes in the nucleus.
About this StructureAbout this Structure
1BG1 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Three-dimensional structure of the Stat3beta homodimer bound to DNA., Becker S, Groner B, Muller CW, Nature. 1998 Jul 9;394(6689):145-51. PMID:9671298
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