4a9y: Difference between revisions
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<StructureSection load='4a9y' size='340' side='right' caption='[[4a9y]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4a9y' size='340' side='right' caption='[[4a9y]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4a9y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[4a9y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A9Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A9Y FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand= | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AQZ:N-(3-{[7-METHOXY-6-(2-PYRROLIDIN-1-YLETHOXY)QUINAZOLIN-4-YL]AMINO}-4-METHYLPHENYL)-2-MORPHOLIN-4-YLISONICOTINAMIDE'>AQZ</scene><br> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2baj|2baj]], [[1wfc|1wfc]], [[3zsi|3zsi]], [[1w7h|1w7h]], [[1wbo|1wbo]], [[1kv2|1kv2]], [[1yqj|1yqj]], [[1bmk|1bmk]], [[1bl7|1bl7]], [[1zyj|1zyj]], [[1a9u|1a9u]], [[1wbt|1wbt]], [[2i0h|2i0h]], [[3zs5|3zs5]], [[2yiw|2yiw]], [[2baq|2baq]], [[1zz2|1zz2]], [[1wbv|1wbv]], [[1di9|1di9]], [[1w83|1w83]], [[1bl6|1bl6]], [[3zsh|3zsh]], [[1m7q|1m7q]], [[1ian|1ian]], [[1oz1|1oz1]], [[1wbn|1wbn]], [[3zya|3zya]], [[2bak|2bak]], [[3zsg|3zsg]], [[2bal|2bal]], [[1wbs|1wbs]], [[1ouy|1ouy]], [[1ouk|1ouk]], [[2y8o|2y8o]], [[2yis|2yis]], [[1r39|1r39]], [[1wbw|1wbw]], [[1kv1|1kv1]], [[1w82|1w82]], [[2yix|2yix]], [[1ove|1ove]], [[1r3c|1r3c]], [[1zzl|1zzl]], [[1w84|1w84]]</td></tr> | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2baj|2baj]], [[1wfc|1wfc]], [[3zsi|3zsi]], [[1w7h|1w7h]], [[1wbo|1wbo]], [[1kv2|1kv2]], [[1yqj|1yqj]], [[1bmk|1bmk]], [[1bl7|1bl7]], [[1zyj|1zyj]], [[1a9u|1a9u]], [[1wbt|1wbt]], [[2i0h|2i0h]], [[3zs5|3zs5]], [[2yiw|2yiw]], [[2baq|2baq]], [[1zz2|1zz2]], [[1wbv|1wbv]], [[1di9|1di9]], [[1w83|1w83]], [[1bl6|1bl6]], [[3zsh|3zsh]], [[1m7q|1m7q]], [[1ian|1ian]], [[1oz1|1oz1]], [[1wbn|1wbn]], [[3zya|3zya]], [[2bak|2bak]], [[3zsg|3zsg]], [[2bal|2bal]], [[1wbs|1wbs]], [[1ouy|1ouy]], [[1ouk|1ouk]], [[2y8o|2y8o]], [[2yis|2yis]], [[1r39|1r39]], [[1wbw|1wbw]], [[1kv1|1kv1]], [[1w82|1w82]], [[2yix|2yix]], [[1ove|1ove]], [[1r3c|1r3c]], [[1zzl|1zzl]], [[1w84|1w84]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a9y RCSB], [http://www.ebi.ac.uk/pdbsum/4a9y PDBsum]</span></td></tr> | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a9y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a9y OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a9y RCSB], [http://www.ebi.ac.uk/pdbsum/4a9y PDBsum]</span></td></tr> | ||
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The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]ben zamide (AZD6703), a clinical p38alpha MAP kinase inhibitor for the treatment of inflammatory diseases.,Brown DS, Cumming JG, Bethel P, Finlayson J, Gerhardt S, Nash I, Pauptit RA, Pike KG, Reid A, Snelson W, Swallow S, Thompson C Bioorg Med Chem Lett. 2012 Jun 15;22(12):3879-83. Epub 2012 May 2. PMID:22608965<ref>PMID:22608965</ref> | The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]ben zamide (AZD6703), a clinical p38alpha MAP kinase inhibitor for the treatment of inflammatory diseases.,Brown DS, Cumming JG, Bethel P, Finlayson J, Gerhardt S, Nash I, Pauptit RA, Pike KG, Reid A, Snelson W, Swallow S, Thompson C Bioorg Med Chem Lett. 2012 Jun 15;22(12):3879-83. Epub 2012 May 2. PMID:22608965<ref>PMID:22608965</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Gerhardt, S.]] | [[Category: Gerhardt, S.]] | ||
[[Category: Hargreaves, D.]] | [[Category: Hargreaves, D.]] | ||
[[Category: Transferase]] | [[Category: Transferase]] |