3t7h: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3t7h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T7H FirstGlance]. <br> | <table><tr><td colspan='2'>[[3t7h]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T7H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3T7H FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t7e|3t7e]], [[3t7f|3t7f]], [[3t7g|3t7g]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3t7e|3t7e]], [[3t7f|3t7f]], [[3t7g|3t7g]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATG7, APG7, CVT2, YHR171W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ATG7, APG7, CVT2, YHR171W ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t7h RCSB], [http://www.ebi.ac.uk/pdbsum/3t7h PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3t7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t7h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3t7h RCSB], [http://www.ebi.ac.uk/pdbsum/3t7h PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/ATG7_YEAST ATG7_YEAST]] E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes.<ref>PMID:9759731</ref> <ref>PMID:8224160</ref> <ref>PMID:7593182</ref> <ref>PMID:10233148</ref> <ref>PMID:10233150</ref> <ref>PMID:11100732</ref> <ref>PMID:11149920</ref> <ref>PMID:12965207</ref> <ref>PMID:15277523</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.,Taherbhoy AM, Tait SW, Kaiser SE, Williams AH, Deng A, Nourse A, Hammel M, Kurinov I, Rock CO, Green DR, Schulman BA Mol Cell. 2011 Nov 4;44(3):451-61. PMID:22055190<ref>PMID:22055190</ref> | Atg8 transfer from atg7 to atg3: a distinctive e1-e2 architecture and mechanism in the autophagy pathway.,Taherbhoy AM, Tait SW, Kaiser SE, Williams AH, Deng A, Nourse A, Hammel M, Kurinov I, Rock CO, Green DR, Schulman BA Mol Cell. 2011 Nov 4;44(3):451-61. PMID:22055190<ref>PMID:22055190</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Deng, A | [[Category: Deng, A]] | ||
[[Category: Green, D R | [[Category: Green, D R]] | ||
[[Category: Hammel, M | [[Category: Hammel, M]] | ||
[[Category: Kaiser, S E | [[Category: Kaiser, S E]] | ||
[[Category: Kurinov, I | [[Category: Kurinov, I]] | ||
[[Category: Nourse, A | [[Category: Nourse, A]] | ||
[[Category: Rock, C O | [[Category: Rock, C O]] | ||
[[Category: Schulman, B A | [[Category: Schulman, B A]] | ||
[[Category: Taherbhoy, A M | [[Category: Taherbhoy, A M]] | ||
[[Category: Tait, S W | [[Category: Tait, S W]] | ||
[[Category: Williams, A H | [[Category: Williams, A H]] | ||
[[Category: Atg7]] | [[Category: Atg7]] | ||
[[Category: Autophagy]] | [[Category: Autophagy]] | ||
[[Category: E1]] | [[Category: E1]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||