3u3v: Difference between revisions

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 == Structural highlights ==
 <table><tr><td colspan='2'>[[3u3v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U3V FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u3p|3u3p]], [[3u3q|3u3q]], [[3u3s|3u3s]], [[3u3t|3u3t]]</td></tr>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u3p|3u3p]], [[3u3q|3u3q]], [[3u3s|3u3s]], [[3u3t|3u3t]]</td></tr>
-<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFRSF21, DR6, UNQ437/PRO868 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFRSF21, DR6, UNQ437/PRO868 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u3v RCSB], [http://www.ebi.ac.uk/pdbsum/3u3v PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u3v RCSB], [http://www.ebi.ac.uk/pdbsum/3u3v PDBsum]</span></td></tr>
-<table>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/TNR21_HUMAN TNR21_HUMAN]] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS.,Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W, Zhang L, Hung LW, Matsugaki N, Wakatsuki S, Liu ZJ Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):521-30. Epub 2012 Apr 17. PMID:22525750<ref>PMID:22525750</ref>
-From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+==See Also==
+*[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]]
 == References ==
 <references/>
@@ Line 20: / Line 25: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Ding, W.]]
+[[Category: Ding, W]]
-[[Category: Hung, L W.]]
+[[Category: Hung, L W]]
-[[Category: Jiao, L Y.]]
+[[Category: Jiao, L Y]]
-[[Category: Liu, Z J.]]
+[[Category: Liu, Z J]]
-[[Category: Matsugaki, N.]]
+[[Category: Matsugaki, N]]
-[[Category: Ru, H.]]
+[[Category: Ru, H]]
-[[Category: Shaw, N.]]
+[[Category: Shaw, N]]
-[[Category: Wakatsuki, S.]]
+[[Category: Wakatsuki, S]]
-[[Category: Zhang, L G.]]
+[[Category: Zhang, L G]]
-[[Category: Zhao, L X.]]
+[[Category: Zhao, L X]]
 [[Category: Apoptosis]]
 [[Category: Trigger apoptosis]]