3se7: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3se7]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SE7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3se7]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SE7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SE7 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3se7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3se7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3se7 RCSB], [http://www.ebi.ac.uk/pdbsum/3se7 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3se7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3se7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3se7 RCSB], [http://www.ebi.ac.uk/pdbsum/3se7 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Antibiotic resistance is ancient.,D'Costa VM, King CE, Kalan L, Morar M, Sung WW, Schwarz C, Froese D, Zazula G, Calmels F, Debruyne R, Golding GB, Poinar HN, Wright GD Nature. 2011 Aug 31. doi: 10.1038/nature10388. PMID:21881561<ref>PMID:21881561</ref> | Antibiotic resistance is ancient.,D'Costa VM, King CE, Kalan L, Morar M, Sung WW, Schwarz C, Froese D, Zazula G, Calmels F, Debruyne R, Golding GB, Poinar HN, Wright GD Nature. 2011 Aug 31. doi: 10.1038/nature10388. PMID:21881561<ref>PMID:21881561</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Morar, M | [[Category: Morar, M]] | ||
[[Category: Wright, G D | [[Category: Wright, G D]] | ||
[[Category: Alpha-beta structure]] | [[Category: Alpha-beta structure]] | ||
[[Category: D-alanine-d-lactate ligase]] | [[Category: D-alanine-d-lactate ligase]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
Revision as of 12:57, 4 January 2015
ancient VanAancient VanA
Structural highlights
Publication Abstract from PubMedThe discovery of antibiotics more than 70 years ago initiated a period of drug innovation and implementation in human and animal health and agriculture. These discoveries were tempered in all cases by the emergence of resistant microbes. This history has been interpreted to mean that antibiotic resistance in pathogenic bacteria is a modern phenomenon; this view is reinforced by the fact that collections of microbes that predate the antibiotic era are highly susceptible to antibiotics. Here we report targeted metagenomic analyses of rigorously authenticated ancient DNA from 30,000-year-old Beringian permafrost sediments and the identification of a highly diverse collection of genes encoding resistance to beta-lactam, tetracycline and glycopeptide antibiotics. Structure and function studies on the complete vancomycin resistance element VanA confirmed its similarity to modern variants. These results show conclusively that antibiotic resistance is a natural phenomenon that predates the modern selective pressure of clinical antibiotic use. Antibiotic resistance is ancient.,D'Costa VM, King CE, Kalan L, Morar M, Sung WW, Schwarz C, Froese D, Zazula G, Calmels F, Debruyne R, Golding GB, Poinar HN, Wright GD Nature. 2011 Aug 31. doi: 10.1038/nature10388. PMID:21881561[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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