3s85: Difference between revisions
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3s85]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S85 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S85 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3s85]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S85 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S85 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LK0:METHYL+N-[(2S)-1-[[(2S,3S,5S)-5-[[(2S)-2-(METHOXYCARBONYLAMINO)-3,3-DIMETHYL-BUTANOYL]AMINO]-3-OXIDANYL-6-PHENYL-1-(4-PYRIDIN-3-YLPHENYL)HEXAN-2-YL]AMINO]-3,3-DIMETHYL-1-OXIDANYLIDENE-BUTAN-2-YL]CARBAMATE'>LK0</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LK0:METHYL+N-[(2S)-1-[[(2S,3S,5S)-5-[[(2S)-2-(METHOXYCARBONYLAMINO)-3,3-DIMETHYL-BUTANOYL]AMINO]-3-OXIDANYL-6-PHENYL-1-(4-PYRIDIN-3-YLPHENYL)HEXAN-2-YL]AMINO]-3,3-DIMETHYL-1-OXIDANYLIDENE-BUTAN-2-YL]CARBAMATE'>LK0</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ggv|3ggv]], [[3gga|3gga]], [[3ggx|3ggx]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ggv|3ggv]], [[3gga|3gga]], [[3ggx|3ggx]]</td></tr> | ||
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])</td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s85 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s85 RCSB], [http://www.ebi.ac.uk/pdbsum/3s85 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s85 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s85 RCSB], [http://www.ebi.ac.uk/pdbsum/3s85 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 14: | Line 14: | ||
2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.,Degoey DA, Grampovnik DJ, Flentge CA, Flosi WJ, Chen HJ, Yeung CM, Randolph JT, Klein LL, Dekhtyar T, Colletti L, Marsh KC, Stoll V, Mamo M, Morfitt DC, Nguyen B, Schmidt JM, Swanson SJ, Mo H, Kati WM, Molla A, Kempf DJ J Med Chem. 2009 Apr 23;52(8):2571-86. PMID:19323562<ref>PMID:19323562</ref> | 2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.,Degoey DA, Grampovnik DJ, Flentge CA, Flosi WJ, Chen HJ, Yeung CM, Randolph JT, Klein LL, Dekhtyar T, Colletti L, Marsh KC, Stoll V, Mamo M, Morfitt DC, Nguyen B, Schmidt JM, Swanson SJ, Mo H, Kati WM, Molla A, Kempf DJ J Med Chem. 2009 Apr 23;52(8):2571-86. PMID:19323562<ref>PMID:19323562</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
| Line 21: | Line 21: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human immunodeficiency virus 1]] | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: DeGoey, D A | [[Category: DeGoey, D A]] | ||
[[Category: Flentge, C A | [[Category: Flentge, C A]] | ||
[[Category: Flosi, W J | [[Category: Flosi, W J]] | ||
[[Category: Grampovnik, D J | [[Category: Grampovnik, D J]] | ||
[[Category: Acid protease]] | [[Category: Acid protease]] | ||
[[Category: Aspartic-type endopepidase activity]] | [[Category: Aspartic-type endopepidase activity]] | ||
[[Category: Beta barrel]] | [[Category: Beta barrel]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||