HMGI(Y): Difference between revisions
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High Mobility Group (HMG) proteins are a class of non-histone chromosomal proteins found in all mammals. HMG proteins recognize and bind DNA and are involved in the regulation of various DNA-dependent processes, such as transcription, recombination and DNA repair.) HMGI(Y) is a High Mobility Group (HMG) protein with two isomers—I and Y. These proteins were isolated from human cells in 1983, and were of particular interest because they exhibit preferential binding to the minor groove of AT rich regions of double-stranded DNA, which is essential to many of its functions. HMGI(Y) proteins have three DNA binding sites, termed AT hook DNA-binding domains, found in discrete locations between amino acids 21 and 89. Overlapping two of the AT hook sites is a region that specifies in interacting with HIPK2. There is also a glutamic acid-rich (acidic) region located at one end of the protein, amino acids 91-106. | High Mobility Group (HMG) proteins are a class of non-histone chromosomal proteins found in all mammals. HMG proteins recognize and bind DNA and are involved in the regulation of various DNA-dependent processes, such as transcription, recombination and DNA repair.) HMGI(Y) is a High Mobility Group (HMG) protein with two isomers—I and Y. These proteins were isolated from human cells in 1983, and were of particular interest because they exhibit preferential binding to the minor groove of AT rich regions of double-stranded DNA, which is essential to many of its functions. HMGI(Y) proteins have three DNA binding sites, termed AT hook DNA-binding domains, found in discrete locations between amino acids 21 and 89. Overlapping two of the AT hook sites is a region that specifies in interacting with HIPK2. There is also a glutamic acid-rich (acidic) region located at one end of the protein, amino acids 91-106. | ||
HMGI(Y) Sequence Length: 107 AA | HMGI(Y) Sequence Length: 107 AA | ||
Molecular Mass: 11750-11858 Da | Molecular Mass: 11750-11858 Da | ||
PDB: P17096 | PDB: P17096 | ||