Tumor necrosis factor: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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 '''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis.  TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome).  It is involved in the regulation of the immune cells.  TNF is a transmembrane homotrimer.  The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).
+</StructureSection>
 == 3D Structures of tumor necrosis factor ==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-===TNF alpha===
+*TNF alpha
-[[1tnf]] – hTNF – human   <BR />
+**[[1tnf]] – hTNF – human   <BR />
-[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]] – hTNF (mutant)   <BR />
+**[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]] – hTNF (mutant)   <BR />
-[[2tnf]] – TNF – mouse   <BR />
+**[[2tnf]] – TNF – mouse   <BR />
-[[2az5]] – hTNF + inhibitor   <BR />
+**[[2az5]] – hTNF + inhibitor   <BR />
-[[3it8]] – hTNF + poxvirus 2L protein   <BR />
+**[[3it8]] – hTNF + poxvirus 2L protein   <BR />
-[[3l9j]] – hTNF + antagonist   <BR />
+**[[3l9j]] – hTNF + antagonist   <BR />
-[[3alq]] – hTNF (mutant) + TNF receptor   <BR />
+**[[3alq]] – hTNF (mutant) + TNF receptor   <BR />
-[[4g3y]], [[3wd5]] – hTNF + antibody  <BR />
+**[[4g3y]], [[3wd5]] – hTNF + antibody  <BR />
-===TNF beta===
+*TNF beta
-[[1tnr]] – hTNF + TNF receptor p55   <BR />
+**[[1tnr]] – hTNF + TNF receptor p55   <BR />
-===TNF ===
+*TNF
-[[2vfj]] – hTNF ovarian tumor domain   <BR />
+**[[2vfj]] – hTNF ovarian tumor domain   <BR />
+}}
 [[Category:Topic Page]]