2xpy: Difference between revisions
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<StructureSection load='2xpy' size='340' side='right' caption='[[2xpy]], [[Resolution|resolution]] 2.73Å' scene=''> | <StructureSection load='2xpy' size='340' side='right' caption='[[2xpy]], [[Resolution|resolution]] 2.73Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xpy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPY OCA]. <br> | <table><tr><td colspan='2'>[[2xpy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XPY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XPY FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xq0|2xq0]], [[2xpz|2xpz]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xq0|2xq0]], [[2xpz|2xpz]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leukotriene-A(4)_hydrolase Leukotriene-A(4) hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.3.2.6 3.3.2.6] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xpy RCSB], [http://www.ebi.ac.uk/pdbsum/2xpy PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xpy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xpy RCSB], [http://www.ebi.ac.uk/pdbsum/2xpy PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/LKHA4_YEAST LKHA4_YEAST]] Aminopeptidase that preferentially cleaves tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze an epoxide moiety of LTA(4) to form LTB(4) (in vitro).<ref>PMID:10574934</ref> <ref>PMID:11601994</ref> <ref>PMID:16024909</ref> <ref>PMID:16597475</ref> <ref>PMID:21146536</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit upon Inhibitor Binding.,Helgstrand C, Hasan M, Uysal H, Haeggstrom JZ, Thunnissen MM J Mol Biol. 2010 Dec 10. PMID:21146536<ref>PMID:21146536</ref> | A Leukotriene A(4) Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit upon Inhibitor Binding.,Helgstrand C, Hasan M, Uysal H, Haeggstrom JZ, Thunnissen MM J Mol Biol. 2010 Dec 10. PMID:21146536<ref>PMID:21146536</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Haeggstrom, J Z | [[Category: Haeggstrom, J Z]] | ||
[[Category: Hasan, M | [[Category: Hasan, M]] | ||
[[Category: Helgstrand, C | [[Category: Helgstrand, C]] | ||
[[Category: Thunnissen, M M.G M | [[Category: Thunnissen, M M.G M]] | ||
[[Category: Usyal, H | [[Category: Usyal, H]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||