2xx3: Difference between revisions
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<StructureSection load='2xx3' size='340' side='right' caption='[[2xx3]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='2xx3' size='340' side='right' caption='[[2xx3]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xx3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XX3 OCA]. <br> | <table><tr><td colspan='2'>[[2xx3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XX3 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TAE:N1-[(E)-4-DIHYDROXYPHOSPHONYL-BUT-2-ENYL]-THYMINE'>TAE</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=TAE:N1-[(E)-4-DIHYDROXYPHOSPHONYL-BUT-2-ENYL]-THYMINE'>TAE</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e2d|1e2d]], [[1e2g|1e2g]], [[1e9a|1e9a]], [[1e9b|1e9b]], [[1e98|1e98]], [[1nn3|1nn3]], [[1e2e|1e2e]], [[1e9e|1e9e]], [[1e2q|1e2q]], [[1e99|1e99]], [[1nmx|1nmx]], [[1nn5|1nn5]], [[1nmz|1nmz]], [[1nn1|1nn1]], [[1e9d|1e9d]], [[1nmy|1nmy]], [[1e2f|1e2f]], [[1nn0|1nn0]], [[1e9f|1e9f]], [[1e9c|1e9c]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e2d|1e2d]], [[1e2g|1e2g]], [[1e9a|1e9a]], [[1e9b|1e9b]], [[1e98|1e98]], [[1nn3|1nn3]], [[1e2e|1e2e]], [[1e9e|1e9e]], [[1e2q|1e2q]], [[1e99|1e99]], [[1nmx|1nmx]], [[1nn5|1nn5]], [[1nmz|1nmz]], [[1nn1|1nn1]], [[1e9d|1e9d]], [[1nmy|1nmy]], [[1e2f|1e2f]], [[1nn0|1nn0]], [[1e9f|1e9f]], [[1e9c|1e9c]]</td></tr> | ||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xx3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xx3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xx3 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xx3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xx3 RCSB], [http://www.ebi.ac.uk/pdbsum/2xx3 PDBsum]</span></td></tr> | ||
<table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/KTHY_HUMAN KTHY_HUMAN]] Catalyzes the conversion of dTMP to dTDP. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.,Topalis D, Pradere U, Roy V, Caillat C, Azzouzi A, Broggi J, Snoeck R, Andrei G, Lin J, Eriksson S, Alexandre JA, El-Amri C, Deville-Bonne D, Meyer P, Balzarini J, Agrofoglio LA J Med Chem. 2011 Jan 13;54(1):222-32. Epub 2010 Dec 3. PMID:21128666<ref>PMID:21128666</ref> | Novel antiviral C5-substituted pyrimidine acyclic nucleoside phosphonates selected as human thymidylate kinase substrates.,Topalis D, Pradere U, Roy V, Caillat C, Azzouzi A, Broggi J, Snoeck R, Andrei G, Lin J, Eriksson S, Alexandre JA, El-Amri C, Deville-Bonne D, Meyer P, Balzarini J, Agrofoglio LA J Med Chem. 2011 Jan 13;54(1):222-32. Epub 2010 Dec 3. PMID:21128666<ref>PMID:21128666</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
==See Also== | |||
*[[Thymidylate kinase|Thymidylate kinase]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: DTMP kinase]] | [[Category: DTMP kinase]] | ||
[[Category: Caillat, C | [[Category: Caillat, C]] | ||
[[Category: Meyer, P | [[Category: Meyer, P]] | ||
[[Category: Acyclic nucleoside phosphonate]] | [[Category: Acyclic nucleoside phosphonate]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||