2yh0: Difference between revisions
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<StructureSection load='2yh0' size='340' side='right' caption='[[2yh0]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | <StructureSection load='2yh0' size='340' side='right' caption='[[2yh0]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2yh0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH0 OCA]. <br> | <table><tr><td colspan='2'>[[2yh0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YH0 FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2u2f|2u2f]], [[1u2f|1u2f]], [[1opi|1opi]], [[1o0p|1o0p]], [[2g4b|2g4b]], [[1jmt|1jmt]], [[2yh4|2yh4]], [[2yh1|2yh1]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2u2f|2u2f]], [[1u2f|1u2f]], [[1opi|1opi]], [[1o0p|1o0p]], [[2g4b|2g4b]], [[1jmt|1jmt]], [[2yh4|2yh4]], [[2yh1|2yh1]]</td></tr> | ||
<tr | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yh0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yh0 RCSB], [http://www.ebi.ac.uk/pdbsum/2yh0 PDBsum]</span></td></tr> | ||
</table> | |||
<table> | == Function == | ||
[[http://www.uniprot.org/uniprot/U2AF2_HUMAN U2AF2_HUMAN]] Necessary for the splicing of pre-mRNA. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10.<ref>PMID:15009664</ref> <ref>PMID:19470458</ref> <ref>PMID:19574390</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.,Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcarcel J, Sattler M Nature. 2011 Jul 13;475(7356):408-11. doi: 10.1038/nature10171. PMID:21753750<ref>PMID:21753750</ref> | Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.,Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcarcel J, Sattler M Nature. 2011 Jul 13;475(7356):408-11. doi: 10.1038/nature10171. PMID:21753750<ref>PMID:21753750</ref> | ||
From | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Gasch, A | [[Category: Gasch, A]] | ||
[[Category: Mackereth, C D | [[Category: Mackereth, C D]] | ||
[[Category: Madl, T | [[Category: Madl, T]] | ||
[[Category: Sattler, M | [[Category: Sattler, M]] | ||
[[Category: Simon, B | [[Category: Simon, B]] | ||
[[Category: Zanier, K | [[Category: Zanier, K]] | ||
[[Category: Mrna processing]] | [[Category: Mrna processing]] | ||
[[Category: Pre-mrna splicing]] | [[Category: Pre-mrna splicing]] | ||
[[Category: Rna binding protein]] | [[Category: Rna binding protein]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||