User:Cody Couperus/Sandbox 1: Difference between revisions
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==Introduction== | ==Introduction== | ||
<scene name='58/583418/Thombin_main_secondary/1'>Thrombin</scene> is the serine protease that catalyzes the penultimate step in blood coagulation. It is activated from its zymogen, prothrombin, at the site of tissue injury by | <scene name='58/583418/Thombin_main_secondary/1'>Thrombin</scene> is the serine protease that catalyzes the penultimate step in blood coagulation. It is activated from its zymogen, prothrombin, at the site of tissue injury by [Factor_Xa | Xa] and its cofactor FVa in the presence of phospholipid membrane and calcium. Thrombin is then able to catalyze the cleavage of fibrinogen to insoluable fibrin which spontaneously polymerizes to form a stable clot. Thrombin also acts as a procoagulant by: | ||
* Activating platelets through their protease activated receptors (PARs) | * Activating platelets through their protease activated receptors (PARs) | ||