4nw3: Difference between revisions

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-{{STRUCTURE_4nw3|  PDB=4nw3  |  SCENE=  }}
-===Crystal structure of MLL CXXC domain in complex with a CpG DNA===
-==Disease==
+==Crystal structure of MLL CXXC domain in complex with a CpG DNA==
+<StructureSection load='4nw3' size='340' side='right' caption='[[4nw3]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4nw3]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NW3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NW3 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KMT2A, ALL1, CXXC7, HRX, HTRX, MLL, MLL1, TRX1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nw3 OCA], [http://pdbe.org/4nw3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nw3 RCSB], [http://www.ebi.ac.uk/pdbsum/4nw3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nw3 ProSAT]</span></td></tr>
+</table>
+== Disease ==
 [[http://www.uniprot.org/uniprot/KMT2A_HUMAN KMT2A_HUMAN]] Acute myeloid leukemia with 11q23 abnormalities;Precursor B-cell acute lymphoblastic leukemia;Wiedemann-Steiner syndrome;Acute biphenotypic leukemia;Acute undifferentiated leukemia;Bilineal acute leukemia. The disease is caused by mutations affecting the gene represented in this entry.  Chromosomal aberrations involving KMT2A are a cause of acute leukemias. Translocation t(1;11)(q21;q23) with MLLT11/AF1Q; translocation t(3;11)(p21;q23) with NCKIPSD/AF3p21; translocation t(3,11)(q25,q23) with GMPS; translocation t(4;11)(q21;q23) with AFF1/MLLT2/AF4; insertion ins(5;11)(q31;q13q23) with AFF4/AF5Q31; translocation t(5;11)(q12;q23) with AF5-alpha/CENPK; translocation t(6;11)(q27;q23) with MLLT4/AF6; translocation t(9;11)(p22;q23) with MLLT3/AF9; translocation t(10;11)(p11.2;q23) with ABI1; translocation t(10;11)(p12;q23) with MLLT10/AF10; t(11;15)(q23;q14) with CASC5 and ZFYVE19; translocation t(11;17)(q23;q21) with MLLT6/AF17; translocation t(11;19)(q23;p13.3) with ELL; translocation t(11;19)(q23;p13.3) with MLLT1/ENL; translocation t(11;19)(q23;p23) with GAS7; translocation t(X;11)(q13;q23) with FOXO4/AFX1. Translocation t(3;11)(q28;q23) with LPP. Translocation t(10;11)(q22;q23) with TET1. Translocation t(9;11)(q34;q23) with DAB2IP. Translocation t(4;11)(p12;q23) with FRYL. Fusion proteins KMT2A-MLLT1, KMT2A-MLLT3 and KMT2A-ELL interact with PPP1R15A and, on the contrary to unfused KMT2A, inhibit PPP1R15A-induced apoptosis.  A chromosomal aberration involving KMT2A may be a cause of chronic neutrophilic leukemia. Translocation t(4;11)(q21;q23) with SEPT11.
+== Function ==
-==Function==
 [[http://www.uniprot.org/uniprot/KMT2A_HUMAN KMT2A_HUMAN]] Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.<ref>PMID:10490642</ref> <ref>PMID:12453419</ref> <ref>PMID:15960975</ref> <ref>PMID:19556245</ref>
-==About this Structure==
+==See Also==
-[[4nw3]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NW3 OCA].
+*[[Histone methyltransferase|Histone methyltransferase]]
+== References ==
-==Reference==
+<references/>
-<references group="xtra"/><references/>
+__TOC__
-[[Category: Arrowsmith, C H.]]
+</StructureSection>
-[[Category: Bian, C.]]
+[[Category: Human]]
-[[Category: Bountra, C.]]
+[[Category: Arrowsmith, C H]]
-[[Category: Chao, X.]]
+[[Category: Bian, C]]
-[[Category: Edwards, A M.]]
+[[Category: Bountra, C]]
-[[Category: Min, J.]]
+[[Category: Chao, X]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Edwards, A M]]
-[[Category: Tempel, W.]]
+[[Category: Min, J]]
-[[Category: Walker, J R.]]
+[[Category: Structural genomic]]
-[[Category: Weigelt, J.]]
+[[Category: Tempel, W]]
+[[Category: Walker, J R]]
+[[Category: Weigelt, J]]
 [[Category: Cg island]]
 [[Category: Cpg island]]
@@ Line 28: / Line 35: @@
 [[Category: Histone-lysine n-methyltransferase]]
 [[Category: Sgc]]
-[[Category: Structural genomics consortium]]