4l1o: Difference between revisions

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{{STRUCTURE_4l1o|  PDB=4l1o  |  SCENE=  }}
==Crystal structure of human ALDH3A1 with inhibitor 1-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-1H-indole-2,3-dione==
===Crystal structure of human ALDH3A1 with inhibitor 1-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-1H-indole-2,3-dione===
<StructureSection load='4l1o' size='340' side='right' caption='[[4l1o]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[4l1o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L1O FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/AL3A1_HUMAN AL3A1_HUMAN]] ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.  
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1VL:(3S)-1-{[4-(1,3-BENZODIOXOL-5-YLMETHYL)PIPERAZIN-1-YL]METHYL}-3-HYDROXY-1,3-DIHYDRO-2H-INDOL-2-ONE'>1VL</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sza|3sza]], [[3szb|3szb]], [[4l2o|4l2o]]</td></tr>
==About this Structure==
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_dehydrogenase_(NAD(P)(+)) Aldehyde dehydrogenase (NAD(P)(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.5 1.2.1.5] </span></td></tr>
[[4l1o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1O OCA].  
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l1o RCSB], [http://www.ebi.ac.uk/pdbsum/4l1o PDBsum]</span></td></tr>
</table>
__TOC__
</StructureSection>
[[Category: Hurley, T D.]]
[[Category: Hurley, T D.]]
[[Category: Parajuli, B.]]
[[Category: Parajuli, B.]]
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[[Category: Nadp+ binding]]
[[Category: Nadp+ binding]]
[[Category: Oxidoreductase-inhibitor complex]]
[[Category: Oxidoreductase-inhibitor complex]]
[[Category: Rossman fold]]
[[Category: Rossmann fold]]

Revision as of 16:57, 3 November 2014

Crystal structure of human ALDH3A1 with inhibitor 1-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-1H-indole-2,3-dioneCrystal structure of human ALDH3A1 with inhibitor 1-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}-1H-indole-2,3-dione

Structural highlights

4l1o is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:Aldehyde dehydrogenase (NAD(P)(+)), with EC number 1.2.1.5
Resources:FirstGlance, OCA, RCSB, PDBsum

4l1o, resolution 2.30Å

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