4py0: Difference between revisions

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OCA

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-'''Unreleased structure'''
+==Crystal structure of P2Y12 receptor in complex with 2MeSATP==
+<StructureSection load='4py0' size='340' side='right' caption='[[4py0]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-The entry 4py0 is ON HOLD
+== Structural highlights ==
+[[4py0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY0 OCA]. <br>
-Authors: Zhang, J., Zhang, K., Gao, Z.G., Paoletta, S., Zhang, D., Han, G.W., Li, T., Ma, L., Zhang, W., Muller, C.E., Yang, H., Jiang, H., Cherezov, V., Katritch, V., Jacobson, K.A., Stevens, R.C., Wu, B., Zhao, Q., GPCR Network (GPCR)
+<b>Related:</b> [[4ntj|4ntj]], [[4pxz|4pxz]]<br>
+<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
-Description: Crystal structure of P2Y12 receptor in complex with 2MeSATP
+== Disease ==
+[[http://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN]] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN]] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Cherezov, V.]]
+[[Category: GPCR, GPCR Network.]]
+[[Category: Gao, Z G.]]
+[[Category: Han, G W.]]
+[[Category: Jacobson, K A.]]
+[[Category: Jiang, H.]]
+[[Category: Katritch, V.]]
+[[Category: Li, T.]]
+[[Category: Ma, L.]]
+[[Category: Muller, C E.]]
+[[Category: Paoletta, S.]]
+[[Category: Stevens, R C.]]
+[[Category: Wu, B.]]
+[[Category: Yang, H.]]
+[[Category: Zhang, D.]]
+[[Category: Zhang, J.]]
+[[Category: Zhang, K.]]
+[[Category: Zhang, W.]]
+[[Category: Zhao, Q.]]
+[[Category: Gpcr]]
+[[Category: Gpcr network]]
+[[Category: Membrane]]
+[[Category: Membrane protein]]
+[[Category: Partial agonist-bound]]
+[[Category: Platelet activation]]
+[[Category: Psi-biology]]
+[[Category: Purinergic receptor p2y12]]
+[[Category: Signaling membrane protein]]
+[[Category: Signaling protein-nucleotide complex]]
+[[Category: Structural genomic]]