Phosphoenolpyruvate carboxylase: Difference between revisions

Revision as of 11:46, 27 June 2016

Phosphoenolpyruvate carboxylase (PEPC) catalyzes the addition of bicarbonate to phosphoenolpyruvate to form oxaloacetate and phosphate. PEPC is part of the carbon fixation process in plants. PEPC is inhibited by aspartate, fumarate and malonate.

Structural highlights

Maze PEPC active site contains an Mn+2 ion^[1].

Structure of E. coli phosphoenolpyruvate carboxylase complex with aspartate and Mn+2 ion (purple) (PDB entry 1qb4)

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3D structures of phosphoenolpyruvate carboxylase3D structures of phosphoenolpyruvate carboxylase

Updated on 27-June-2016

3odm – PEPC + malonate – Clostridium perfringens
3zgb, 3zge – PEPC + aspartate – Flaveria pringlei
1fiy, 1qb4 – EcPEPC + aspartate – Escherichia coli
1jqn – EcPEPC + aspartate + PEP analog
1jqo – PEPC – corn
4bxc – FtPEPC + α-D-glucose-6-phosphate – Flaveria trinervia
4bxh – FtPEPC

ReferencesReferences

↑ Matsumura H, Xie Y, Shirakata S, Inoue T, Yoshinaga T, Ueno Y, Izui K, Kai Y. Crystal structures of C4 form maize and quaternary complex of E. coli phosphoenolpyruvate carboxylases. Structure. 2002 Dec;10(12):1721-30. PMID:12467579

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Lucas Xavier da Cunha, Karsten Theis

[1] Matsumura H, Xie Y, Shirakata S, Inoue T, Yoshinaga T, Ueno Y, Izui K, Kai Y. Crystal structures of C4 form maize and quaternary complex of E. coli phosphoenolpyruvate carboxylases. Structure. 2002 Dec;10(12):1721-30. PMID:12467579

[1]

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 '''Phosphoenolpyruvate carboxylase''' (PEPC) catalyzes the addition of bicarbonate to phosphoenolpyruvate to form oxaloacetate and phosphate.  PEPC is part of the carbon fixation process in plants.  PEPC is inhibited by aspartate, fumarate and malonate.
+== Structural highlights ==
+Maze PEPC active site contains an Mn+2 ion<ref>PMID:12467579</ref>.
+</StructureSection>
 ==3D structures of phosphoenolpyruvate carboxylase==
@@ Line 14: / Line 17: @@
 [[4bxc]] – FtPEPC + α-D-glucose-6-phosphate – ''Flaveria trinervia''<br />
 [[4bxh]] – FtPEPC<br />
+== References ==
+<references/>
 [[Category:Topic Page]]