User:Alexander Rudecki/Sandbox 1: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Introduction== | ==Introduction== | ||
<Structure load='4F9U' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | |||
''Drosophila melanogaster'' glutaminyl cyclase (DromeQC but also known as CG10487 CG32412 or Dmel\CG32412) is a globular protein part of the α/β-hydrolase superfamily. DromeQC is an aminoacyltransferase (EC 2.3.2.5) that acts on N-terminal glutamine or glutamate residues, producing a stable cap resistant to protease degradation. The human orthologue of DromeQC (hQC) has been implicated in stabilizing amyloid Aβ peptides involved in neurodegenerative disorders such as Alzheimers<ref name="schilling">PMID: 18836460</ref>. It has been shown that DromeQC has a similar overall fold to hQC, as well as a conserved active site<ref name="main">PMID: 22897232</ref>. Thus DromeQC is an attractive candidate for transgenic models and mechanistic studies. | ''Drosophila melanogaster'' glutaminyl cyclase (DromeQC but also known as CG10487 CG32412 or Dmel\CG32412) is a globular protein part of the α/β-hydrolase superfamily. DromeQC is an aminoacyltransferase (EC 2.3.2.5) that acts on N-terminal glutamine or glutamate residues, producing a stable cap resistant to protease degradation. The human orthologue of DromeQC (hQC) has been implicated in stabilizing amyloid Aβ peptides involved in neurodegenerative disorders such as Alzheimers<ref name="schilling">PMID: 18836460</ref>. It has been shown that DromeQC has a similar overall fold to hQC, as well as a conserved active site<ref name="main">PMID: 22897232</ref>. Thus DromeQC is an attractive candidate for transgenic models and mechanistic studies. | ||