Sandbox Reserved 919: Difference between revisions
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{{Johnson_CH462_Spring2014}} | {{Johnson_CH462_Spring2014}} | ||
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=Monoglyeride Lipase= | |||
[[Image:MGLProt.jpg|300 px|left|thumb|Monomer of MGL created in PYMOL (PDB:3PE6)]] | [[Image:MGLProt.jpg|300 px|left|thumb|Monomer of MGL created in PYMOL (PDB:3PE6)]] | ||
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'''Monoglyceride Lipase''' ('''MGL''', '''MAGL''', '''MGLL''') is a 33 kDa [http://en.wikipedia.org/wiki/Protein protein] found mostly in the cell membrane. It is a member of the [http://en.wikipedia.org/wiki/Serine_hydrolase serine hydrolase] superfamily and is also classified as part of the [http://en.wikipedia.org/wiki/Alpha/beta_hydrolase_fold α/β hydrolase fold] family. MGL plays a key role in the hydrolysis of 2-arachidonoylglycerol (2-AG), an endocannabinoid that exists in neurons of the central nervous system, into arachidonic acid and glycerol. Due to the vast medical and therapeutic utility of 2-AG, the inhibition of MGL is a high interest target in pharmaceutical research. <ref> PMID:19962385 </ref> | '''Monoglyceride Lipase''' ('''MGL''', '''MAGL''', '''MGLL''') is a 33 kDa [http://en.wikipedia.org/wiki/Protein protein] found mostly in the cell membrane. It is a member of the [http://en.wikipedia.org/wiki/Serine_hydrolase serine hydrolase] superfamily and is also classified as part of the [http://en.wikipedia.org/wiki/Alpha/beta_hydrolase_fold α/β hydrolase fold] family. MGL plays a key role in the hydrolysis of 2-arachidonoylglycerol (2-AG), an endocannabinoid that exists in neurons of the central nervous system, into arachidonic acid and glycerol. Due to the vast medical and therapeutic utility of 2-AG, the inhibition of MGL is a high interest target in pharmaceutical research. <ref> PMID:19962385 </ref> | ||
==Structure== | ==Structure== | ||
<StructureSection load='3PE6' size='350' frame='true' align='right' scene='57/573133/Generic_monomer/3' caption= 'Structure'> | |||
This is the structure of the enzyme. | This is the structure of the enzyme. | ||
<scene name='57/573133/Generic_monomer/3'>Default View</scene> | <scene name='57/573133/Generic_monomer/3'>Default View</scene> | ||
===Active Site=== | |||
<scene name='57/573133/Ligand_showing/1'>Ligand Bound</scene> | <scene name='57/573133/Ligand_showing/1'>Ligand Bound</scene> | ||
<p><scene name='57/573134/Catalytic_triad/2'>Catalytic Triad</scene></p> | <p><scene name='57/573134/Catalytic_triad/2'>Catalytic Triad</scene></p> | ||