4kgc: Difference between revisions
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{{STRUCTURE_4kgc| PDB=4kgc | SCENE= }} | {{STRUCTURE_4kgc| PDB=4kgc | SCENE= }} | ||
===Nucleosome Core Particle Containing (ETA6-P-CYMENE)-(1, 2-ETHYLENEDIAMINE)-RUTHENIUM=== | ===Nucleosome Core Particle Containing (ETA6-P-CYMENE)-(1, 2-ETHYLENEDIAMINE)-RUTHENIUM=== | ||
{{ABSTRACT_PUBMED_24637564}} | |||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4kgc]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGC OCA]. | [[4kgc]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGC OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:024637564</ref><references group="xtra"/><references/> | |||
[[Category: African clawed frog]] | |||
[[Category: Adhireksan, Z.]] | [[Category: Adhireksan, Z.]] | ||
[[Category: Davey, C A.]] | [[Category: Davey, C A.]] | ||
Revision as of 10:27, 16 April 2014
Nucleosome Core Particle Containing (ETA6-P-CYMENE)-(1, 2-ETHYLENEDIAMINE)-RUTHENIUMNucleosome Core Particle Containing (ETA6-P-CYMENE)-(1, 2-ETHYLENEDIAMINE)-RUTHENIUM
Template:ABSTRACT PUBMED 24637564
FunctionFunction
[H2B11_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [H4_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
About this StructureAbout this Structure
4kgc is a 10 chain structure with sequence from African clawed frog. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Adhireksan Z, Davey GE, Campomanes P, Groessl M, Clavel CM, Yu H, Nazarov AA, Yeo CH, Ang WH, Droge P, Rothlisberger U, Dyson PJ, Davey CA. Ligand substitutions between ruthenium-cymene compounds can control protein versus DNA targeting and anticancer activity. Nat Commun. 2014 Mar 18;5:3462. doi: 10.1038/ncomms4462. PMID:24637564 doi:http://dx.doi.org/10.1038/ncomms4462