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''' | ==X-ray Structure of the Adduct formed between cisplatin and Ribonuclease A== | ||
<StructureSection load='4ot4' size='340' side='right' caption='[[4ot4]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ot4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OT4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OT4 FirstGlance]. <br> | |||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene><br> | |||
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jvt|1jvt]]</td></tr> | |||
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ot4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ot4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ot4 RCSB], [http://www.ebi.ac.uk/pdbsum/4ot4 PDBsum]</span></td></tr> | |||
<table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The crystal structure of the main adduct formed in the reaction between cisplatin and bovine pancreatic ribonuclease is reported here. Notably, in both of the protein molecules present in the asymmetric unit, platinum(II) binding takes place exclusively at the level of Met29. In one of the two molecules, the Gln28 side chain completes the platinum coordination sphere, anchoring the cisplatin fragment to the protein in a bidentate fashion. These results contain interesting implications for understanding the biological chemistry of this important drug. | |||
Cisplatin binding to proteins: molecular structure of the ribonuclease a adduct.,Messori L, Merlino A Inorg Chem. 2014 Apr 21;53(8):3929-31. doi: 10.1021/ic500360f. Epub 2014 Apr 3. PMID:24694179<ref>PMID:24694179</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Pancreatic ribonuclease]] | |||
[[Category: Merlino, A.]] | |||
[[Category: Messori, L.]] | |||
[[Category: Hydrolase]] | |||
[[Category: Rnase a fold]] | |||
Revision as of 10:26, 9 July 2014
X-ray Structure of the Adduct formed between cisplatin and Ribonuclease AX-ray Structure of the Adduct formed between cisplatin and Ribonuclease A
Structural highlights
Publication Abstract from PubMedThe crystal structure of the main adduct formed in the reaction between cisplatin and bovine pancreatic ribonuclease is reported here. Notably, in both of the protein molecules present in the asymmetric unit, platinum(II) binding takes place exclusively at the level of Met29. In one of the two molecules, the Gln28 side chain completes the platinum coordination sphere, anchoring the cisplatin fragment to the protein in a bidentate fashion. These results contain interesting implications for understanding the biological chemistry of this important drug. Cisplatin binding to proteins: molecular structure of the ribonuclease a adduct.,Messori L, Merlino A Inorg Chem. 2014 Apr 21;53(8):3929-31. doi: 10.1021/ic500360f. Epub 2014 Apr 3. PMID:24694179[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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