4cu4: Difference between revisions

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-'''Unreleased structure'''
+{{STRUCTURE_4cu4|  PDB=4cu4  |  SCENE=  }}
+===FhuA from E. coli in complex with the lasso peptide microcin J25 (MccJ25)===
-The entry 4cu4 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/FHUA_ECOLI FHUA_ECOLI]] This receptor binds the ferrichrome-iron ligand. It interacts with the TonB protein, which is responsible for energy coupling of the ferrichrome-promoted iron transport system. Acts as a receptor for bacteriophage T5 as well as T1, phi80 and colicin M. Binding of T5 triggers the opening of a high conductance ion channel. Can also transport the antibiotic albomycin.<ref>PMID:8617231</ref>  [[http://www.uniprot.org/uniprot/MCJA_ECOLX MCJA_ECOLX]] Peptide antibiotic that functions through inhibition of the bacterial DNA-dependent RNA polymerase (RNAP). May inhibit transcription by binding in RNAP secondary channel and blocking nucleotide substrates access to the catalytic center. Exhibits potent bacteriocidal activity against a range of Enterobacteriaceae, including several pathogenic E.coli, Salmonella and Shigella strains. Also acts on the cytoplasmic membrane of Salmonella newport, producing alteration of membrane permeability and disruption of the subsequent gradient dissipation, which inhibits several processes essential for cell viability, such as oxygen consumption. Induces bacterial filamentation in susceptible cells in a non-SOS-dependent way, but this phenotype may result from impaired transcription of genes coding for cell division proteins.<ref>PMID:11731133</ref> <ref>PMID:11443089</ref> <ref>PMID:12401787</ref>
-Authors: Mathavan, I., Rebuffat, S., Beis, K.
+==About this Structure==
+[[4cu4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli_str._k-12_substr._mc4100 Escherichia coli str. k-12 substr. mc4100]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CU4 OCA].
-Description: FhuA from E. coli in complex with the lasso peptide microcin J25 (MccJ25)
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Escherichia coli str. k-12 substr. mc4100]]
+[[Category: Beis, K.]]
+[[Category: Mathavan, I.]]
+[[Category: Rebuffat, S.]]
+[[Category: Detergent]]
+[[Category: Lipopolysaccharide]]
+[[Category: Transport protein-antibiotic complex]]