Lactate Dehydrogenase: Difference between revisions
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<StructureSection load='' size='450' side='right' scene='Lactate_Dehydrogenase/Cv/5' caption='Lactate dehydrogenase dimer complex with cofactor NAD and pyruvate (PDB code [[2fm3]])'> | <StructureSection load='' size='450' side='right' scene='Lactate_Dehydrogenase/Cv/5' caption='Lactate dehydrogenase dimer complex with cofactor NAD and pyruvate (PDB code [[2fm3]])'> | ||
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The <scene name='Lactate_Dehydrogenase/Secondary/2'>secondary structure</scene> of LDH as shown here is comprised of 40% alpha helices and 23% beta sheets<ref name="2nd">http://www.cheric.org/ippage/e/ipdata/2004/05/file/e200405-701.pdf </ref>. The SCOP data classifies this form of lactate dehydrogenase as mixed beta-alpha-beta, with mainly parallel beta sheets. | The <scene name='Lactate_Dehydrogenase/Secondary/2'>secondary structure</scene> of LDH as shown here is comprised of 40% alpha helices and 23% beta sheets<ref name="2nd">http://www.cheric.org/ippage/e/ipdata/2004/05/file/e200405-701.pdf </ref>. The SCOP data classifies this form of lactate dehydrogenase as mixed beta-alpha-beta, with mainly parallel beta sheets. | ||
===Catalysis=== | ===Catalysis=== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
===L-LDH=== | |||
[[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR /> | [[2e37]], [[2v6m]] – TtL-LDH – ''Thermus thermophilus''<BR /> | ||
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[[3ks0]] - LDH residues 86-180 + flavocytochrome b2 heme domain + FAB B2B4 | [[3ks0]] - LDH residues 86-180 + flavocytochrome b2 heme domain + FAB B2B4 | ||
''L-LDH binary complex'' | |||
[[2ydn]], [[4b7u]] – PfL-LDH + bicine<BR /> | [[2ydn]], [[4b7u]] – PfL-LDH + bicine<BR /> | ||
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[[4i8x]], [[4i9h]], [[4i9n]], [[4i9u]] – rLDH A chain + pyridine derivative - rabbit<br /> | [[4i8x]], [[4i9h]], [[4i9n]], [[4i9u]] – rLDH A chain + pyridine derivative - rabbit<br /> | ||
''L-LDH ternary complex with inhibitor'' | |||
[[1u5c]] - PfL-LDH + inhibitor + NAD<BR /> | [[1u5c]] - PfL-LDH + inhibitor + NAD<BR /> | ||
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[[9ldb]], [[9ldt]] - pL-LDH + oxamate + NAD – pig | [[9ldb]], [[9ldt]] - pL-LDH + oxamate + NAD – pig | ||
''L-LDH ternary complex with reactants'' | |||
[[1sow]], [[1pzh]] - TgL-LDH + oxalate + NAD<BR /> | [[1sow]], [[1pzh]] - TgL-LDH + oxalate + NAD<BR /> | ||