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==Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4== | |||
<StructureSection load='4iy4' size='340' side='right' caption='[[4iy4]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
==Disease== | <table><tr><td colspan='2'>[[4iy4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IY4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IY4 FirstGlance]. <br> | ||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4iy0|4iy0]], [[4iy2|4iy2]], [[4iy3|4iy3]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CNNM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iy4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iy4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4iy4 RCSB], [http://www.ebi.ac.uk/pdbsum/4iy4 PDBsum]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[[http://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN]] Familial primary hypomagnesemia with normocalcuria and normocalcemia. The disease is caused by mutations affecting the gene represented in this entry. | [[http://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN]] Familial primary hypomagnesemia with normocalcuria and normocalcemia. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN]] Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | [[http://www.uniprot.org/uniprot/CNNM2_HUMAN CNNM2_HUMAN]] Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). | ||
__TOC__ | |||
</StructureSection> | |||
[[ | [[Category: Human]] | ||
[[Category: Accardi, A | [[Category: Accardi, A]] | ||
[[Category: Corral-Rodriguez, M A | [[Category: Corral-Rodriguez, M A]] | ||
[[Category: Diercks, T | [[Category: Diercks, T]] | ||
[[Category: Encinar, J A | [[Category: Encinar, J A]] | ||
[[Category: Ereno-Orbea, J | [[Category: Ereno-Orbea, J]] | ||
[[Category: Gomez-Garcia, I | [[Category: Gomez-Garcia, I]] | ||
[[Category: Martinez-Cruz, L A | [[Category: Martinez-Cruz, L A]] | ||
[[Category: Muller, D | [[Category: Muller, D]] | ||
[[Category: Oyenarte, I | [[Category: Oyenarte, I]] | ||
[[Category: Spiwok, V | [[Category: Spiwok, V]] | ||
[[Category: Stuiver, M | [[Category: Stuiver, M]] | ||
[[Category: Terashima, H | [[Category: Terashima, H]] | ||
[[Category: Bateman domain]] | [[Category: Bateman domain]] | ||
[[Category: Cbs domain]] | [[Category: Cbs domain]] | ||
Revision as of 16:33, 4 January 2015
Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4Structural and ligand binding properties of the Bateman domain of human magnesium transporters CNNM2 and CNNM4
Structural highlights
Disease[CNNM2_HUMAN] Familial primary hypomagnesemia with normocalcuria and normocalcemia. The disease is caused by mutations affecting the gene represented in this entry. Function[CNNM2_HUMAN] Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity). |
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