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==Crystal Structure of putative 2-dehydropantoate 2-reductase PanE from Mycobacterium tuberculosis complexed with NADP and oxamate== | |||
<StructureSection load='4ol9' size='340' side='right' caption='[[4ol9]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
==Function== | <table><tr><td colspan='2'>[[4ol9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OL9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OL9 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=OXM:OXAMIC+ACID'>OXM</scene></td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv2573, MT2649, MTCY227.28c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/2-dehydropantoate_2-reductase 2-dehydropantoate 2-reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.169 1.1.1.169] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ol9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ol9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ol9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ol9 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/PANE_MYCTU PANE_MYCTU]] Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity). | [[http://www.uniprot.org/uniprot/PANE_MYCTU PANE_MYCTU]] Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity). | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: 2-dehydropantoate 2-reductase]] | [[Category: 2-dehydropantoate 2-reductase]] | ||
[[Category: | [[Category: Structural genomic]] | ||
[[Category: Ketopantoate reductase]] | [[Category: Ketopantoate reductase]] | ||
[[Category: National institute of allergy and infectious disease]] | [[Category: National institute of allergy and infectious disease]] | ||
[[Category: Niaid]] | [[Category: Niaid]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Ssgcid]] | [[Category: Ssgcid]] | ||
Revision as of 21:32, 25 December 2014
Crystal Structure of putative 2-dehydropantoate 2-reductase PanE from Mycobacterium tuberculosis complexed with NADP and oxamateCrystal Structure of putative 2-dehydropantoate 2-reductase PanE from Mycobacterium tuberculosis complexed with NADP and oxamate
Structural highlights
Function[PANE_MYCTU] Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity). |
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