4ml3: Difference between revisions

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-{{STRUCTURE_4ml3|  PDB=4ml3  |  SCENE=  }}
+==X-ray structure of ComE D58A REC domain from Streptococcus pneumoniae==
-===X-ray structure of ComE D58A REC domain from Streptococcus pneumoniae===
+<StructureSection load='4ml3' size='340' side='right' caption='[[4ml3]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
-{{ABSTRACT_PUBMED_24500202}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ml3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Strr6 Strr6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ML3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ML3 FirstGlance]. <br>
+</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4b1n|4b1n]], [[4mld|4mld]]</td></tr>
+<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">comE, spr2041 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=171101 STRR6])</td></tr>
+<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ml3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ml3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ml3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ml3 PDBsum]</span></td></tr>
+<table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Natural transformation contributes to the maintenance and to the evolution of the bacterial genomes. In Streptococcus pneumoniae, this function is reached by achieving the competence state, which is under the control of the ComD-ComE two-component system. We present the crystal and solution structures of ComE. We mimicked the active and non-active states by using the phosphorylated mimetic ComED58E and the unphosphorylatable ComED58A mutants. In the crystal, full-length ComED58A dimerizes through its canonical REC receiver domain but with an atypical mode, which is also adopted by the isolated RECD58A and RECD58E. The LytTR domain adopts a tandem arrangement consistent with the two direct repeats of its promoters. However ComED58A is monomeric in solution, as seen by SAXS, by contrast to ComED58E that dimerizes. For both, a relative mobility between the two domains is assumed. Based on these results we propose two possible ways for activation of ComE by phosphorylation.
-==About this Structure==
+Structural insights into the dimerization of the response regulator ComE from Streptococcus pneumoniae.,Boudes M, Sanchez D, Graille M, van Tilbeurgh H, Durand D, Quevillon-Cheruel S Nucleic Acids Res. 2014 Feb 5. PMID:24500202<ref>PMID:24500202</ref>
-[[4ml3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ML3 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:024500202</ref><references group="xtra"/><references/>
+</div>
+==See Also==
+*[[Response regulator|Response regulator]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Strr6]]
 [[Category: Boudes, M.]]
 [[Category: Durand, D.]]