4ot8: Difference between revisions
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{{STRUCTURE_4ot8| PDB=4ot8 | SCENE= }} | |||
===X-ray Crystal Structure of Serine Hydroxymethyl Transferase from Burkholderia cenocepacia bound to PLP and Serine=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/B4ECY9_BURCJ B4ECY9_BURCJ]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).[HAMAP-Rule:MF_00051] | |||
==About this Structure== | |||
[[4ot8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OT8 OCA]. | |||
[[Category: Glycine hydroxymethyltransferase]] | |||
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]] | |||
[[Category: National institute of allergy and infectious disease]] | |||
[[Category: Niaid]] | |||
[[Category: Seattle structural genomics center for infectious disease]] | |||
[[Category: Serine hydroxymethyl transferase]] | |||
[[Category: Ssgcid]] | |||
[[Category: Structural genomic]] | |||
[[Category: Transferase]] |