CD3: Difference between revisions
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
===CD3 ε chain=== | |||
[[1a81]] – hCD3 ITAM + Syk kinase – human <BR /> | [[1a81]] – hCD3 ITAM + Syk kinase – human <BR /> | ||
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[[3r08]] – mCD3 extracellular domain + antibody<BR /> | [[3r08]] – mCD3 extracellular domain + antibody<BR /> | ||
===CD3 εγ dimer=== | |||
[[1jbj]] – hCD3 extracellular domain - NMR<BR /> | [[1jbj]] – hCD3 extracellular domain - NMR<BR /> | ||
[[1sy6]] – hCD3 extracellular domain + antibody<BR /> | [[1sy6]] – hCD3 extracellular domain + antibody<BR /> | ||
===CD3 εδ dimer=== | |||
[[1xiw]] – hCD3 extracellular domain + antibody<BR /> | [[1xiw]] – hCD3 extracellular domain + antibody<BR /> | ||
[[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR /> | [[1xmw]] – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep<BR /> | ||
===CD3 ζ chain=== | |||
[[1ygr]], [[2oq1]] – hCD3 ITAM + CD45 protein tyrosine phosphatase <BR /> | [[1ygr]], [[2oq1]] – hCD3 ITAM + CD45 protein tyrosine phosphatase <BR /> | ||
Revision as of 10:23, 17 August 2014
<StructureSection load='1sy6' size='350' side='right' caption='Structure of human CD3 extracellular domain (grey) complex with antibody light chain (aqua) and heavy chain (red) (PDB entry 1sy6)' scene=>
CD3 (or Cluster of Differentiation 3) is a T-cell co-receptor. The CD3 is composed of γ, δ and two ε chains. These 4 chains associate with the T-cell receptor (TCR) and a ζ chain to form an activation signal in T lymphocytes. CD3 assembles as 3 pairs of dimers: εγ, εδ and ζζ. The intracellular domain of CD3 contains a single immunorecetor tyrosine-based activation motif (ITAM). Drugs which bind to CD3 are tested as immunorepressants.
3D structures of CD33D structures of CD3
Updated on 17-August-2014
CD3 ε chainCD3 ε chain
1a81 – hCD3 ITAM + Syk kinase – human
2jxb – hCD3 domain SH3-1
2k4f – mCD3 ITAM – mouse - NMR
3r08 – mCD3 extracellular domain + antibody
CD3 εγ dimerCD3 εγ dimer
1jbj – hCD3 extracellular domain - NMR
1sy6 – hCD3 extracellular domain + antibody
CD3 εδ dimerCD3 εδ dimer
1xiw – hCD3 extracellular domain + antibody
1xmw – mCD3 extracellular domain ε/sCD3 extracellular domain δ – sheep
CD3 ζ chainCD3 ζ chain
1ygr, 2oq1 – hCD3 ITAM + CD45 protein tyrosine phosphatase
3ik5, 3ioz – hCD3 ITAM + NEF
2hac – hCD3 transmembrane domain - NMR