4co8: Difference between revisions

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{{STRUCTURE_4co8|  PDB=4co8  |  SCENE=  }}
==Structure of the DNA binding ETS domain of human ETV4==
===Structure of the DNA binding ETS domain of human ETV4===
<StructureSection load='4co8' size='340' side='right' caption='[[4co8]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
 
== Structural highlights ==
==Disease==
<table><tr><td colspan='2'>[[4co8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CO8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4co8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4co8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4co8 RCSB], [http://www.ebi.ac.uk/pdbsum/4co8 PDBsum]</span></td></tr>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/ETV4_HUMAN ETV4_HUMAN]] Ewing sarcoma.   
[[http://www.uniprot.org/uniprot/ETV4_HUMAN ETV4_HUMAN]] Ewing sarcoma.   
 
== Function ==
==Function==
[[http://www.uniprot.org/uniprot/ETV4_HUMAN ETV4_HUMAN]] Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.<ref>PMID:19307308</ref>   
[[http://www.uniprot.org/uniprot/ETV4_HUMAN ETV4_HUMAN]] Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.<ref>PMID:19307308</ref>   
 
== References ==
==About this Structure==
<references/>
[[4co8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CO8 OCA].
__TOC__
 
</StructureSection>
==Reference==
[[Category: Human]]
<references group="xtra"/><references/>
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith, C H.]]
[[Category: Bountra, C]]
[[Category: Bountra, C.]]
[[Category: Burgess-Brown, N]]
[[Category: Burgess-Brown, N.]]
[[Category: Cooper, C D.O]]
[[Category: Cooper, C D.O.]]
[[Category: Delft, F von]]
[[Category: Delft, F von.]]
[[Category: Edwards, A M]]
[[Category: Edwards, A M.]]
[[Category: Gileadi, O]]
[[Category: Gileadi, O.]]
[[Category: Kopec, J]]
[[Category: Kopec, J.]]
[[Category: Newman, J A]]
[[Category: Newman, J A.]]
[[Category: Shrestha, L]]
[[Category: Shrestha, L.]]
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 20:26, 21 December 2014

Structure of the DNA binding ETS domain of human ETV4Structure of the DNA binding ETS domain of human ETV4

Structural highlights

4co8 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, RCSB, PDBsum

Disease

[ETV4_HUMAN] Ewing sarcoma.

Function

[ETV4_HUMAN] Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.[1]

References

  1. ↑ Guo B, Sharrocks AD. Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3. Mol Cell Biol. 2009 Jun;29(11):3204-18. doi: 10.1128/MCB.01128-08. Epub 2009 Mar , 23. PMID:19307308 doi:http://dx.doi.org/10.1128/MCB.01128-08

4co8, resolution 1.05Å

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