4mjb: Difference between revisions

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-{{STRUCTURE_4mjb|  PDB=4mjb  |  SCENE=  }}
+==Synechocystis sp. PCC 6803 glutaredoxin A-A79S==
-===Synechocystis sp. PCC 6803 glutaredoxin A-A79S===
+<StructureSection load='4mjb' size='340' side='right' caption='[[4mjb]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
-{{ABSTRACT_PUBMED_24298277}}
+== Structural highlights ==
+[[4mjb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Syny3 Syny3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJB OCA]. <br>
+<b>Related:</b> [[3qmx|3qmx]], [[4mja|4mja]], [[4mjc|4mjc]], [[4mje|4mje]]<br>
+<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
+== Publication Abstract from PubMed ==
+Glutaredoxin from the cyanobacterium Synechocystis sp. PCC 6803 is a small protein, containing only 88 amino acids, that participates in a large number of redox reactions, serving both as an electron donor for enzyme-catalyzed reductions and as a regulator of diverse metabolic pathways. The crystal structures of glutaredoxins from several species have been solved, including the glutaredoxin A isoform from the cyanobacterium Synechocystis sp. PCC 6803. We have utilized the small size of Synechocystis glutaredoxin A and its propensity to form protein crystals that diffract to high resolution to explore a long-standing question in biochemistry; i.e., what are the effects of mutations on protein structure and function? Taking advantage of these properties, we have initiated a long-term educational project that would examine the structural and biochemical changes in glutaredoxin as a function of single-point mutational replacements. Here, we report some of the mutational effects that we have observed to date.
-==Function==
+Utility of Synechocystis sp. PCC 6803 glutaredoxin A as a platform to study high-resolution mutagenesis of proteins.,Knaff DB, Sutton RB Front Plant Sci. 2013 Nov 15;4:461. doi: 10.3389/fpls.2013.00461. eCollection, 2013. PMID:24298277<ref>PMID:24298277</ref>
-[[http://www.uniprot.org/uniprot/GLRX2_SYNY3 GLRX2_SYNY3]] Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity).
-==About this Structure==
+From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
-[[4mjb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Syny3 Syny3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MJB OCA].
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:024298277</ref><references group="xtra"/><references/>
+</StructureSection>
 [[Category: Syny3]]
 [[Category: Knaff, D B.]]