2za1: Difference between revisions

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Revision as of 19:53, 20 March 2008

File:2za1.jpg

, resolution 2.65Å

Sites:

and

Ligands:

Activity:

Orotidine-5'-phosphate decarboxylase, with EC number 4.1.1.23

Coordinates:

save as pdb, mmCIF, xml

Crystal Structure of orotidine 5'-monophosphate decarboxylase complexed with orotidine 5'-monophosphate from P.falciparum

OverviewOverview

Orotidine 5'-monophoshate decarboxylase (OMPDC) catalyses the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP). Here, we report the X-ray analysis of apo, substrate or product-complex forms of OMPDC from Plasmodium falciparum (PfOMPDC) at 2.7, 2.65 and 2.65 A, respectively. The structural analysis provides the substrate recognition mechanism with dynamic structural changes, as well as the rearrangement of the hydrogen bond array at the active site. The structural basis of substrate or product binding to PfOMPDC will help to uncover the decarboxylation mechanism and facilitate structure-based optimization of antimalarial drugs.

About this StructureAbout this Structure

2ZA1 is a Single protein structure of sequence from Plasmodium falciparum. Full crystallographic information is available from OCA.

ReferenceReference

Structural Basis for the Decarboxylation of Orotidine 5'-Monophosphate (OMP) by Plasmodium Falciparum OMP Decarboxylase., Tokuoka K, Kusakari Y, Krungkrai SR, Matsumura H, Kai Y, Krungkrai J, Horii T, Inoue T, J Biochem. 2008 Jan;143(1):69-78. Epub 2007 Nov 1. PMID:17981823

Page seeded by OCA on Thu Mar 20 18:53:14 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:2za1.jpg|left|200px]]<br /><applet load="2za1" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:2za1.jpg|left|200px]]
-caption="2za1, resolution 2.65&Aring;" />
-'''Crystal Structure of orotidine 5'-monophosphate decarboxylase complexed with orotidine 5'-monophosphate from P.falciparum'''<br />
+ {{Structure
+|PDB= 2za1 |SIZE=350|CAPTION= <scene name='initialview01'>2za1</scene>, resolution 2.65&Aring;
+|SITE= <scene name='pdbsite=AC1:Omp+Binding+Site+For+Residue+A+500'>AC1</scene> and <scene name='pdbsite=AC2:Omp+Binding+Site+For+Residue+B+600'>AC2</scene>
+|LIGAND= <scene name='pdbligand=OMP:OROTIDINE-5'-MONOPHOSPHATE'>OMP</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23]
+|GENE=
+}}
+'''Crystal Structure of orotidine 5'-monophosphate decarboxylase complexed with orotidine 5'-monophosphate from P.falciparum'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-ZA1 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] with <scene name='pdbligand=OMP:'>OMP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] Known structural/functional Sites: <scene name='pdbsite=AC1:Omp+Binding+Site+For+Residue+A+500'>AC1</scene> and <scene name='pdbsite=AC2:Omp+Binding+Site+For+Residue+B+600'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZA1 OCA].
+ZA1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZA1 OCA].
 ==Reference==
-Structural Basis for the Decarboxylation of Orotidine 5'-Monophosphate (OMP) by Plasmodium Falciparum OMP Decarboxylase., Tokuoka K, Kusakari Y, Krungkrai SR, Matsumura H, Kai Y, Krungkrai J, Horii T, Inoue T, J Biochem. 2008 Jan;143(1):69-78. Epub 2007 Nov 1. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17981823 17981823]
+Structural Basis for the Decarboxylation of Orotidine 5'-Monophosphate (OMP) by Plasmodium Falciparum OMP Decarboxylase., Tokuoka K, Kusakari Y, Krungkrai SR, Matsumura H, Kai Y, Krungkrai J, Horii T, Inoue T, J Biochem. 2008 Jan;143(1):69-78. Epub 2007 Nov 1. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17981823 17981823]
 [[Category: Orotidine-5'-phosphate decarboxylase]]
 [[Category: Plasmodium falciparum]]
@@ Line 23: / Line 32: @@
 [[Category: pyrimidine biosynthesis]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 19:01:07 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:53:14 2008''