2mju: Difference between revisions
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{{STRUCTURE_2mju| PDB=2mju | SCENE= }} | |||
===Solution structure of a C terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PTBP2_HUMAN PTBP2_HUMAN]] RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.<ref>PMID:11003644</ref> <ref>PMID:12667457</ref> | |||
==About this Structure== | |||
[[2mju]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJU OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Allain, F H.T.]] | |||
[[Category: Blatter, M.]] | |||
[[Category: Esteve, V.]] | |||
[[Category: Nptb]] | |||
[[Category: Splicing]] | |||
Revision as of 08:12, 13 February 2014
Solution structure of a C terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)Solution structure of a C terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB)
FunctionFunction
[PTBP2_HUMAN] RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. Beside its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA.[1] [2]
About this StructureAbout this Structure
2mju is a 1 chain structure. Full experimental information is available from OCA.
ReferenceReference
- ↑ Markovtsov V, Nikolic JM, Goldman JA, Turck CW, Chou MY, Black DL. Cooperative assembly of an hnRNP complex induced by a tissue-specific homolog of polypyrimidine tract binding protein. Mol Cell Biol. 2000 Oct;20(20):7463-79. PMID:11003644
- ↑ Mitchell SA, Spriggs KA, Coldwell MJ, Jackson RJ, Willis AE. The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr. Mol Cell. 2003 Mar;11(3):757-71. PMID:12667457