4hoe: Difference between revisions
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{{STRUCTURE_4hoe| PDB=4hoe | SCENE= }} | |||
===Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111E)=== | |||
{{ABSTRACT_PUBMED_24568657}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DYR_CANAX DYR_CANAX]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
==About this Structure== | |||
[[4hoe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HOE OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:024568657</ref><references group="xtra"/><references/> | |||
[[Category: Dihydrofolate reductase]] | |||
[[Category: Anderson, A C.]] | |||
[[Category: Paulsen, J L.]] | |||
[[Category: Antifungal agent]] | |||
[[Category: Candida albican]] | |||
[[Category: Drug design]] | |||
[[Category: Enzyme inhibitor]] | |||
[[Category: Fungal protein]] | |||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | |||
[[Category: Structure-activity relationship]] | |||
[[Category: Tetrahydrofolate dehydrogenase]] | |||
Revision as of 12:06, 19 March 2014
Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111E)Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (UCP111E)
Template:ABSTRACT PUBMED 24568657
FunctionFunction
[DYR_CANAX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this StructureAbout this Structure
4hoe is a 2 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ G-Dayanandan N, Paulsen JL, Viswanathan K, Keshipeddy S, Lombardo MN, Zhou W, Lamb KM, Sochia AE, Alverson JB, Priestley ND, Wright DL, Anderson AC. Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata. J Med Chem. 2014 Mar 6. PMID:24568657 doi:http://dx.doi.org/10.1021/jm401916j