Sandbox Reserved 830: Difference between revisions
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Oncostatin M, also called OSM, is encoded by the OSM gene and is mostly produced in the end of the activation of macrophages and T cells. OSM belongs to the family of gp130 cytokines implying that it signals through the receptors containing gp130. OSM has been shown to have a lot of pleiotropic functions in cell proliferation, differentiation and inflammatory response. Thus, studies highlight its roles in cancer, bone and liver metabolism alteration, as well as in severe inflammatory diseases, such as lung and skin inflammatory | Oncostatin M, also called OSM, is encoded by the OSM gene and is mostly produced in the end of the activation of macrophages and T cells. OSM belongs to the family of gp130 cytokines implying that it signals through the receptors containing gp130. OSM has been shown to have a lot of pleiotropic functions in cell proliferation, differentiation and inflammatory response. Thus, studies highlight its roles in cancer, bone and liver metabolism alteration, as well as in severe inflammatory diseases, such as lung and skin inflammatory diseases, atherosclerosis, cardiovascular diseases, and rheumatoid polyarthritis. | ||
{{STRUCTURE_1evs| PDB=1evs | SCENE= }} | {{STRUCTURE_1evs| PDB=1evs | SCENE= }} | ||
===Human Oncostatin M=== | ===Human Oncostatin M=== | ||