Sandbox Reserved 818: Difference between revisions
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cAMP is primary in many biological processes that's why its accumulation leads to the disruption of cellular metabolism and pathological events, according to infected cells. <br /> | cAMP is primary in many biological processes that's why its accumulation leads to the disruption of cellular metabolism and pathological events, according to infected cells. <br /> | ||
Thus biological activities of PTX are especially ''histamine sensitization'', ''islet activation'' and ''lymphocytosis''. | Thus biological activities of PTX are especially ''histamine sensitization'', ''islet activation'' and ''lymphocytosis''. | ||
==Structural informations allow to produce efficient vaccine== | |||
Cristal structure provided insight into the pathogenic mechanisms of PTX. Informations about the tertiary structure of the active site a good basis for elimination of the catalytic activity in recombinant molecules for vaccine use. | |||
For example, one highly detoxified PTX analog contains two alterations in the S1 subunit (Arg9 to Lys; Glu129 to Gly), each of which is able to totally abolish the enzymativ activity of the toxin. This molecule already belongs to the new-generation of pertussis vaccines <ref name="Karzon90"> | |||
Edwards, K. M., & Karzon, D. T. (1990). Pertussis vaccines. Pediatric clinics of North America, 37(3), 549. | |||
</ref>. | |||
==See Also== | ==See Also== | ||