Sandbox Reserved 817: Difference between revisions

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Revision as of 22:34, 8 January 2014 view source Adrien Mahler-Wohlgemuth (talk \| contribs) 114 edits No edit summary ← Older edit		Revision as of 22:36, 8 January 2014 view source Adrien Mahler-Wohlgemuth (talk \| contribs) 114 edits No edit summary Newer edit →
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	In mouse and human brain, native BACE1 occurs as a dimer. Dimerization is dependent on membrane attachment and increases BACE1 affinity and turnover rate toward APPSWE-like peptides when compared to the monomeric, soluble form. The different enzymatic properties of monomeric and dimeric BACE1 need to be considered in future drug screening and development processes. <ref> PMID:22363289 </ref>		In mouse and human brain, native BACE1 occurs as a dimer. Dimerization is dependent on membrane attachment and increases BACE1 affinity and turnover rate toward APPSWE-like peptides when compared to the monomeric, soluble form. The different enzymatic properties of monomeric and dimeric BACE1 need to be considered in future drug screening and development processes. <ref =name""> PMID:22363289 </ref>